Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis

被引:1
|
作者
Wu, Liwen [1 ,2 ]
Zhang, Longze [3 ]
Huang, Minglei [1 ,2 ]
Wu, Yan [1 ,2 ]
Jin, Sikan [1 ,2 ]
Zhang, Yaqi [1 ,2 ]
Gan, Xinyun [1 ,2 ]
Yu, Ting [1 ,2 ]
Yu, Guang [1 ,2 ]
Zhang, Jidong [1 ,2 ]
Wang, Xianyao [1 ,2 ]
机构
[1] Zunyi Med Univ, Dept Immunol, Zunyi 563003, Peoples R China
[2] Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi 563000, Peoples R China
[3] Zunyi Med Univ, Affiliated Hosp 3, Sci Res Ctr, Zunyi 563003, Peoples R China
基金
中国国家自然科学基金;
关键词
mesenchymal stem cells; cell-free therapy; exosomes; autoimmune hepatitis; targeted delivery; immunomodulation; STROMAL CELLS; T-CELLS; EXTRACELLULAR VESICLES; DENDRITIC CELLS; LIVER; ACTIVATION; DELIVERY; SUBSETS; INJURY; MSC;
D O I
10.3390/biom14111353
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently faces limited treatment options. In its advanced stages, AIH can progress to liver fibrosis and cirrhosis. Recent research has increasingly focused on cell-free therapies, particularly the use of mesenchymal stem cell (MSC)-derived exosomes (Exos), which have shown promise in treating autoimmune diseases, including AIH. MSC-Exos, as microvesicles with low immunogenicity, high safety, and permeability, can deliver RNA, DNA, proteins, lipids, and various drugs for disease treatment, showing promising clinical application prospects. This review provides a comprehensive summary of the current research on MSC-Exos in the treatment of autoimmune hepatitis (AIH) and explores the underlying molecular mechanisms involved. It highlights the significant regulatory effects of MSC-Exos on immune cells and their ability to modify the microenvironment, demonstrating anti-inflammatory and anti-fibrotic properties while promoting liver regeneration. Additionally, this review also discusses potential challenges and future strategies for advancing Exo-based therapies in the treatment of AIH.
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页数:17
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