Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients

被引:0
作者
Zhang, Yu [1 ]
Gu, Yu-lu [1 ]
Zhang, Wan-fen [1 ]
Li, Xiao-ping [1 ]
Xu, Lin-fang [1 ]
Liu, Tong-qiang [1 ]
机构
[1] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Nephrol, Changzhou 213003, Peoples R China
基金
中国国家自然科学基金;
关键词
Hemodialysis; cognitive impairment; high-sensitivity C-reactive protein; left ventricular hypertrophy; synergy; VASCULAR RISK-FACTORS; CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS; IMPAIRMENT; INFLAMMATION; ASSOCIATION; PREVENTION; MARKERS; STATE; MASS;
D O I
10.1080/0886022X.2025.2450522
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To examine the effects of high-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) on the cognitive function of hemodialysis (HD) patients, and to explore the relationship between hs-CRP, LVH, and cognitive impairment (CI). Methods: A cross-sectional study was conducted on 232 HD patients. Besides, general clinical data were gathered, and patients' cognitive functions were assessed using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ). CI risk factors were screened using logistic regression modeling based on hs-CRP values (low risk <1 mg/L, intermediate risk 1-3 mg/L, and high risk >3 mg/L) and LVH status (normal and hypertrophic) groupings. The synergistic effect of hs-CRP and LVH on CI was also analyzed using the EpiR package. Results: Among HD patients, 122 (52.59%) patients had CI. Multifactorial logistic regression analysis showed that the following factors were associated with an increased risk of CI in HD patients: age (OR = 1.048; 95% CI 1.014-1.083; p = 0.005), LVH (OR = 3.741; 95% CI 1.828-7.657; p < 0.001), and high-risk hs-CRP levels (>3 mg/L; OR = 3.238; 95% CI 1.349-7.768; p = 0.009). In addition, there was a significant synergy between hs-CRP high risk (>3 mg/L) and LVH. Conclusion: Age, LVH, and high risk of hs-CRP (>3 mg/L) were independent risk factors for CI in HD patients. Moreover, HD patients with both hs-CRP high risk (>3.0 mg/L) and LVH were at higher risk of developing CI, and lowering hs-CRP levels and preventing LVH may prevent CI.
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页数:10
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