Paxillin and Kindlin: Research Progress and Biological Functions

被引：0

作者：

Li, Zijian ^{[1
]}

Shao, Ruonan ^{[1
]}

Xin, Honglei ^{[1
]}

Zhu, Yilin ^{[1
]}

Jiang, Suyu ^{[1
]}

Wu, Jiao ^{[1
]}

Yan, Han ^{[1
]}

Jia, Tongyu ^{[1
]}

Ge, Mengyu ^{[1
]}

Shi, Xiaofeng ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 2, 262 North Zhongshan Rd, Nanjing 210003, Peoples R China

来源：

BIOMOLECULES | 2025年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

paxillin; kindlin; cell adhesion; integrin activation; focal adhesion; tumor metastasis; immune response; therapeutic targets; FOCAL ADHESION KINASE; INTEGRIN ALPHA-IIB-BETA-3 ACTIVATION; TUMOR-CELL MIGRATION; TALIN HEAD DOMAIN; BREAST-CANCER; SIGNALING PATHWAY; RHO-GTPASES; PROSTATE-CANCER; STRUCTURAL BASIS; RAC ACTIVATION;

D O I：

10.3390/biom15020173

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paxillin and kindlin are essential regulatory proteins involved in cell adhesion, migration, and signal transduction. Paxillin influences cytoskeletal dynamics by interacting with multiple signaling proteins, while kindlin regulates integrin activation, affecting adhesion and motility. This review examines the structures and functions of these proteins, focusing on their roles in cancer progression, immune response, and therapeutic potential. The cooperation between paxillin and kindlin in integrin activation and focal adhesion dynamics offers valuable insights into tumor metastasis, immune function, and tissue repair.

引用

页数：25

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