Aspilactonol J: A New Cytotoxic Polyketide Isolated from the Marine-Derived Fungus Aspergillus sp. w2-13

被引：0

作者：

Huang, Xiaomei ^{[1
]}

Lin, Shan ^{[3
]}

Li, Guangyu ^{[2
]}

Shao, Zongze ^{[2
]}

Wang, Weiyi ^{[2
]}

Xia, Jinmei ^{[2
]}

机构：

[1] Xiamen Ocean Vocat Coll, Sch Marine Biol, Xiamen Key Lab Intelligent Fishery, Appl Technol Engn Ctr Fujian Prov Higher Educ Mari, Xiamen 361100, Peoples R China

[2] Xiamen Univ, Affiliated Hosp 1, Dept Orthoped, Xiamen, Peoples R China

[3] Xiamen Univ, Affiliated Hosp 1, Dept Orthoped, Xiamen 361003, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2024年 / 18卷 / 05期

关键词：

Aspergillus; Polyketide; NMR; ECD; TDDFT; cytotoxic;

D O I：

10.25135/rnp.477.2406.3552

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Marine-derived Aspergillus sp. strain w2-13, isolated from Dongshan Island in Fujian Province, produced five compounds through solid-state fermentation. This included a new polyketide, aspilactonol J (1), and four previously identified compounds (2-5).. The structure of the new compound was determined using NMR, HRMS, and ECD, supported by theoretical calculations. A plausible biosynthetic pathway for polyketides 1-3 was also proposed. Cytotoxicity tests on various cancer cell lines revealed that aspilactonol J (1) exhibited significant selectivity and efficacy, especially against HepG2 cells, suggesting its potential for pharmaceutical development. This study highlights the role of marine fungi as valuable sources of bioactive natural products with therapeutic potential.

引用

页码：526 / 531

页数：6

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