Extracellular Vesicles as Biomarkers in Infectious Diseases

被引：0
作者：
Cruz, Cinthia Gonzalez [1 ]
Sodawalla, Husain M. [2 ]
Mohanakumar, Thalachallour [3 ]
Bansal, Sandhya [3 ]
机构：
[1] St Josephs Hosp, Barrow Neurol Inst, Phoenix, AZ 85013 USA
[2] No Arizona Univ, Dept Mech Engn, Flagstaff, AZ 86011 USA
[3] St Josephs Hosp, Norton Thorac Inst, Phoenix, AZ 85013 USA
来源：
BIOLOGY-BASEL | 2025年 / 14卷 / 02期
关键词：
extracellular vesicles; biomarkers; disease detection; MEMBRANE-VESICLES; EXOSOMES; BIOGENESIS; VIRUS; SECRETION; VIMENTIN; PROTEINS; LUNG; TRANSPLANT; EXPRESSION;
D O I：
10.3390/biology14020182
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Extracellular vesicles (EVs) are nanosized vesicles that are secreted by all cells into the extracellular space. EVs are involved in cell-to-cell communication and can be found in different bodily fluids (bronchoalveolar lavage fluid, sputum, and urine), tissues, and in circulation; the composition of EVs reflects the physiological condition of the releasing cell. The ability to use EVs from bodily fluids for minimally invasive detection to monitor diseases makes them an attractive target. EVs carry a snapshot of the releasing cell's internal state, and they can serve as powerful biomarkers for diagnosing diseases. EVs also play a role in the body's immune and pathogen detection responses. Pathogens, such as bacteria and viruses, can exploit EVs to enhance their survival and spread and to evade detection by the immune system. Changes in the number or contents of EVs can signal the presence of an infection, offering a potential avenue for developing new diagnostic methods for infectious diseases. Ongoing research in this area aims to address current challenges and the potential of EVs as biomarkers in diagnosing a range of diseases, including infections and infectious diseases. There is limited literature on the development of EVs as diagnostic biomarkers for infectious diseases using existing molecular biology approaches. We aim to address this gap by reviewing recent EV-related investigations in infectious disease studies.
引用
收藏
页数：16
相关论文
共 136 条
  • [1] Murray C.J.L., The Global Burden of Disease Study at 30 years, Nat. Med, 28, pp. 2019-2026, (2022)
  • [2] Global burden associated with 85 pathogens in 2019: A systematic analysis for the Global Burden of Disease Study 2019, Lancet Infect. Dis, 24, pp. 868-895, (2024)
  • [3] Global mortality associated with 33 bacterial pathogens in 2019: A systematic analysis for the Global Burden of Disease Study 2019, Lancet, 400, pp. 2221-2248, (2022)
  • [4] Phillips W., Willms E., Hill A.F., Understanding extracellular vesicle and nanoparticle heterogeneity: Novel methods and considerations, Proteomics, 21, (2021)
  • [5] Hallal S., Tuzesi A., Grau G.E., Buckland M.E., Alexander K.L., Understanding the extracellular vesicle surface for clinical molecular biology, J. Extracell. Vesicles, 11, (2022)
  • [6] Jeppesen D.K., Zhang Q., Franklin J.L., Coffey R.J., Extracellular vesicles and nanoparticles: Emerging complexities, Trends Cell Biol, 33, pp. 667-681, (2023)
  • [7] Rashed M.H., Bayraktar E., Helal G.K., Abd-Ellah M.F., Amero P., Chavez-Reyes A., Rodriguez-Aguayo C., Exosomes: From Garbage Bins to Promising Therapeutic Targets, Int. J. Mol. Sci, 18, (2017)
  • [8] Colombo M., Raposo G., Thery C., Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles, Annu. Rev. Cell Dev. Biol, 30, pp. 255-289, (2014)
  • [9] Costa-Silva B., Aiello N.M., Ocean A.J., Singh S., Zhang H., Thakur B.K., Becker A., Hoshino A., Mark M.T., Molina H., Et al., Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver, Nat. Cell Biol, 17, pp. 816-826, (2015)
  • [10] Arakelyan A., Fitzgerald W., Zicari S., Vanpouille C., Margolis L., Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue, Sci. Rep, 7, (2017)
12345678910