Novel Biomarkers for Early Detection of Hepatocellular Carcinoma

被引：2

作者：

Attia, Abdelrahman M. ^{[1
]}

Rezaee-Zavareh, Mohammad Saeid ^{[2
]}

Hwang, Soo Young ^{[3
]}

Kim, Naomy ^{[1
]}

Adetyan, Hasmik ^{[1
]}

Yalda, Tamar ^{[1
]}

Chen, Pin-Jung ^{[4
]}

Koltsova, Ekaterina K. ^{[5
]}

Yang, Ju Dong ^{[1
,6
,7
]}

机构：

[1] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA

[2] Middle East Liver Dis MELD Ctr, Tehran 1417935840, Iran

[3] Univ Maryland, Dept Internal Med, Med Ctr, Midtown Campus, Baltimore, MD 21201 USA

[4] Cedars Sinai Med Ctr, Dept Hematol & Oncol, Los Angeles, CA 90048 USA

[5] Cedars Sinai Med Ctr, Smidt Heart Inst, Cedars Sinai Canc, Los Angeles, CA 90048 USA

[6] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Los Angeles, CA 90048 USA

[7] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

来源：

DIAGNOSTICS | 2024年 / 14卷 / 20期

基金：

美国国家卫生研究院;

关键词：

liver neoplasms; hepatocellular carcinoma; early detection of cancer; biomarkers; diagnosis: screening; surveillance; GAMMA-CARBOXY PROTHROMBIN; PATIENT-REPORTED BARRIERS; CIRCULATING MICRORNAS; ALPHA-FETOPROTEIN; GROWTH-FACTOR; LIVER-CANCER; DIAGNOSIS; SURVEILLANCE; PLASMA; SERUM;

D O I：

10.3390/diagnostics14202278

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally. Most patients present with late diagnosis, leading to poor prognosis. This narrative review explores novel biomarkers for early HCC detection. We conducted a comprehensive literature review analyzing protein, circulating nucleic acid, metabolite, and quantitative proteomics-based biomarkers, evaluating the advantages and limitations of each approach. While established markers like alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin, and AFP-L3 remain relevant, promising candidates include circulating tumor DNA, microRNAs, long noncoding RNAs, extracellular vesicle, and metabolomic biomarkers. Multi-biomarker panels like the GALAD score, Oncoguard, and Helio liver test show promise for improved diagnostic accuracy. Non-invasive approaches like urine and gut microbiome analysis are also emerging possibilities. Integrating these novel biomarkers with current screening protocols holds significant potential for earlier HCC detection and improved patient outcomes. Future research should explore multi-biomarker panels, omics technologies, and artificial intelligence to further enhance early HCC diagnosis and management.

引用

页数：20

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