Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment

被引:0
作者
Pindiprolu, Sai Kiran S. S. [1 ]
Singh, Madhu Tanya [2 ]
Magham, Sai Varshini [3 ]
Kumar, Chirravuri S. Phani [1 ]
Dasari, Nagasen [1 ]
Gummadi, Ramakrishna [1 ]
Krishnamurthy, Praveen Thaggikuppe [2 ]
机构
[1] Aditya Univ, Sch Pharm, Surampalem, Andhra Pradesh, India
[2] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, 20 Rocklands, Ooty 643001, Tamil nadu, India
[3] Vignan Pharm Coll, Dept Pharmacol, Guntur, India
关键词
CGAS-STING pathway; Cancer microenvironment; Immune system activation; Cancer advancement; Immunotherapeutic interventions; Nanocarriers; ANTITUMOR EFFICACY; MODIFIED LIPOSOMES; DI-GMP; CANCER; NANOPARTICLES; DELIVERY; AGONISTS; ACTIVATION; THERAPY; COMBINATION;
D O I
10.1007/s00210-025-03835-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The cGAS-STING signaling plays an important role in the immune response in a tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The acute and controlled activation of cGAS-STING signaling results in tumor suppression, while chronic activation of cGAS-STING signaling results in immune-suppressive TME that could result in tumor survival. There is a need, therefore, to develop therapeutic strategies for harnessing tumor suppressive effects of cGAS-STING signaling while minimizing the risks associated with chronic activation. Combination therapies and nanocarriers-based delivery of cGAS-STING agonists have emerged as promising strategies in immunotherapy for controlled modulation of cGAS-STING signaling in cancer. These approaches aim to optimize the tumor suppressive effects of the cGAS-STING pathway while minimizing the challenges associated with modulators of cGAS-STING signaling. In the present review, we discuss recent advancements and strategies in combination therapies and nanocarrier-based delivery systems for effectively controlling cGAS-STING signaling in cancer immunotherapy. Further, we emphasized the significance of nanocarrier-based approaches for effective targeting of the cGAS-STING signaling, tackling resistance mechanisms, and overcoming key challenges like immune suppression, tumor heterogeneity, and off-target effects.
引用
收藏
页数:29
相关论文
共 50 条
  • [41] Intervention of cGAS-STING signaling in sterile inflammatory diseases
    Hong, Ze
    Mei, Jiahao
    Guo, Hanli
    Zhu, Juanjuan
    Wang, Chen
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2022, 14 (02)
  • [42] Targeting cGAS-STING pathway for reprogramming tumor-associated macrophages to enhance anti-tumor immunotherapy
    Zhang, Weiyue
    Huang, Xin
    [J]. BIOMARKER RESEARCH, 2025, 13 (01)
  • [43] The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
    Mohseni, Ghazal
    Li, Juan
    Ariston Gabriel, Abakundana Nsenga
    Du, Lutao
    Wang, Yun-shan
    Wang, Chuanxin
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [44] Nanoparticle targeting cGAS-STING signaling in disease therapy
    Zhou, Lan
    Huang, Yu
    Wu, Yuzhang
    Tang, Shupei
    [J]. NANO RESEARCH, 2024, : 7315 - 7336
  • [45] The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
    Liao, Weinian
    Du, Changhong
    Wang, Junping
    [J]. FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [46] The cGAS-STING pathway in COPD: targeting its role and therapeutic potential
    Liao, Kexin
    Wang, Fengshuo
    Xia, Chenhao
    Xu, Ze
    Zhong, Sen
    Bi, Wenqi
    Ruan, Jingjing
    [J]. RESPIRATORY RESEARCH, 2024, 25 (01)
  • [47] Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
    Li, Qiumei
    Tian, Shuoran
    Liang, Jiadi
    Fan, Jiqiang
    Lai, Junzhong
    Chen, Qi
    [J]. FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [48] Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment
    Kho, Vera M.
    Mekers, Vera E.
    Span, Paul N.
    Bussink, Johan
    Adema, Gosse J.
    [J]. CELLULAR IMMUNOLOGY, 2021, 362
  • [49] Specific activation of cGAS-STING pathway by nanotherapeutics- mediated ferroptosis evoked endogenous signaling for boosting systemic tumor immunotherapy
    Liang, Jun-Long
    Jin, Xiao-Kang
    Zhang, Shi-Man
    Huang, Qian-Xiao
    Ji, Ping
    Deng, Xin-Chen
    Cheng, Si-Xue
    Chen, Wei-Hai
    Zhang, Xian-Zheng
    [J]. SCIENCE BULLETIN, 2023, 68 (06) : 622 - 636
  • [50] Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway
    Zhang, Xuewu
    Bai, Xiao-chen
    Chen, Zhijian J.
    [J]. IMMUNITY, 2020, 53 (01) : 43 - 53