Functional mechanisms and potential therapeutic strategies for lactylation in liver diseases

被引:0
作者
Xu, Rong [1 ]
Hao, Yitong [2 ,3 ]
Liu, Yahui [1 ]
Ji, Bai [1 ]
Tian, Weibo [2 ,3 ]
Zhang, Wei [1 ]
机构
[1] Jilin Univ, Hosp 1, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Jilin, Peoples R China
[3] Jilin Univ, Hosp 1, Neurosci Ctr, Changchun 130021, Jilin, Peoples R China
关键词
Lactylation; Glycolysis; Lactate; Liver disease; Pharmacology; Treatment; MESSENGER-RNA; LACTATE; PROTEIN; EXPRESSION; FAMILY; CELLS; GENE; STEATOHEPATITIS; TRANSLATION; GLYCOLYSIS;
D O I
10.1016/j.lfs.2025.123395
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Lactylation, a novel form of lactate-mediated protein post-translational modification (PTM), has been identified as a crucial regulator of gene expression and protein function through the modification of both histone and nonhistone proteins. Liver disease is frequently characterized by a reprogramming of glucose metabolism and subsequent lactate accumulation. Recent research has implicated lactylation in a diverse array of hepatic pathologies, including liver injury, non-alcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma. Consequently, lactylation has emerged as a pivotal regulatory mechanism in liver disease pathogenesis. This review aims to elucidate the intricate regulatory and functional mechanisms underlying lactylation, synthesize recent advancements in its role in various liver diseases, and highlight its potential as a therapeutic target for future interventions in hepatic disorders.
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页数:11
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共 110 条
  • [1] The Emerging Facets of Non-Cancerous Warburg Effect
    Abdel-Haleem, Alyaa M.
    Lewis, Nathan E.
    Jamshidi, Neema
    Mineta, Katsuhiko
    Gao, Xin
    Gojobori, Takashi
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2017, 8
  • [2] RNA-binding protein nucleolin in disease
    Abdelmohsen, Kotb
    Gorospe, Myriam
    [J]. RNA BIOLOGY, 2012, 9 (06) : 799 - 808
  • [3] Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells
    Akkiz, Hikmet
    Gieseler, Robert K.
    Canbay, Ali
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (14)
  • [4] Burden of liver diseases in the world
    Asrani, Sumeet K.
    Devarbhavi, Harshad
    Eaton, John
    Kamath, Patrick S.
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : 151 - 171
  • [5] SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis
    Athwal, Varinder S.
    Pritchett, James
    Llewellyn, Jessica
    Martin, Katherine
    Camacho, Elizabeth
    Raza, Sayyid M. A.
    Phythian-Adams, Alexander
    Birchall, Lindsay J.
    Mullan, Aoibheann F.
    Su, Kim
    Pearmain, Laurence
    Dolman, Grace
    Zaitoun, Abed M.
    Friedman, Scott L.
    MacDonald, Andrew
    Irving, William L.
    Guha, Indra N.
    Hanley, Neil A.
    Hanley, Karen Piper
    [J]. EMBO MOLECULAR MEDICINE, 2017, 9 (12) : 1696 - 1710
  • [6] Cholangiocarcinoma 2020: the next horizon in mechanisms and management
    Banales, Jesus M.
    Marin, Jose J. G.
    Lamarca, Angela
    Rodrigues, Pedro M.
    Khan, Shahid A.
    Roberts, Lewis R.
    Cardinale, Vincenzo
    Carpino, Guido
    Andersen, Jesper B.
    Braconi, Chiara
    Calvisi, Diego F.
    Perugorria, Maria J.
    Fabris, Luca
    Boulter, Luke
    Macias, Rocio I. R.
    Gaudio, Eugenio
    Alvaro, Domenico
    Gradilone, Sergio A.
    Strazzabosco, Mario
    Marzioni, Marco
    Coulouarn, Cedric
    Fouassier, Laura
    Raggi, Chiara
    Invernizzi, Pietro
    Mertens, Joachim C.
    Moncsek, Anja
    Rizvi, Sumera
    Heimbach, Julie
    Koerkamp, Bas Groot
    Bruix, Jordi
    Forner, Alejandro
    Bridgewater, John
    Valle, Juan W.
    Gores, Gregory J.
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (09) : 557 - 588
  • [7] De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers
    Belew, Getachew Debas
    Jones, John G.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, 52 (03)
  • [8] Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
    Bernal, W
    Donaldson, N
    Wyncoll, D
    Wendon, J
    [J]. LANCET, 2002, 359 (9306) : 558 - 563
  • [9] The Science and Translation of Lactate Shuttle Theory
    Brooks, George A.
    [J]. CELL METABOLISM, 2018, 27 (04) : 757 - 785
  • [10] Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma
    Cai, Jialiang
    Song, Lina
    Zhang, Feng
    Wu, Suiyi
    Zhu, Guiqi
    Zhang, Peiling
    Chen, Shiping
    Du, Junxian
    Wang, Biao
    Cai, Yufan
    Yang, Yi
    Wan, Jinglei
    Zhou, Jian
    Fan, Jia
    Dai, Zhi
    [J]. CANCER COMMUNICATIONS, 2024, 44 (11) : 1231 - 1260