The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex

被引:0
作者
Jung, Eujene [1 ]
Kook, Hyun Yi [2 ]
Ryu, Seok Jin [1 ]
Ryu, Hyun Ho [1 ]
Kim, Ho Goon [3 ]
机构
[1] Chonnam Natl Univ, Med Sch, Dept Emergency Med, Gwangju, South Korea
[2] Nambu Univ, Dept Nursing, Gwangju, South Korea
[3] Chonnam Natl Univ, Med Sch, Dept Gastroenterol, Gwangju, South Korea
关键词
vitamin B-12; stroke; sex; risk factor; cohort; ISCHEMIC-STROKE; B VITAMINS; HOMOCYSTEINE; RISK; FOLATE; COBALAMIN; DISEASE; B-12;
D O I
10.1016/j.tjnut.2024.08.002
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Previous studies reported that vitamin B-12 deficiency fi ciency is associated with an increased risk of stroke. However, studies examining the association between excessive vitamin B-12 and stroke risk are limited. Our study aimed to investigate the relationship between excessive vitamin B-12 concentrations and risk of stroke and explore whether this association varies according to sex. Methods: Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were vitamin B-12 plasma concentration and sex. The occurrence of stroke served as the main outcome of interest. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis. An interaction analysis was conducted to assess the interaction effect of vitamin B-12 and sex on stroke incidence. Results: Cox proportional logistic regression analysis, adjusting for confounders, showed that excessive vitamin B-12 did not significantly alter stroke risk (HR: 1.22, 95% CI: 0.82, 1.71) and revealed no significant sex-based differences in stroke risk (HR: 0.90, 95% CI: 0.75, 1.04). However, interaction analysis indicated that excessive vitamin B-12 was linked to a significant fi cant increase in stroke risk in males (HR: 1.81, 95% CI: 1.10, 2.99) but not in females (HR: 1.04, 95% CI: 0.66, 1.60), with statistically significant interaction effect (P < 0.01). Conclusions: Our study demonstrated that although excessive vitamin B-12 alone does not significantly increase stroke risk, it increases risk in males when considering the interaction with sex.
引用
收藏
页码:3012 / 3018
页数:7
相关论文
共 34 条
  • [1] The pathophysiology of elevated vitamin B12 in clinical practice
    Andres, E.
    Serraj, K.
    Zhu, J.
    Vermorken, A. J. M.
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2013, 106 (06) : 505 - 515
  • [2] Aspiration Pneumonia After Stroke: Intervention and Prevention
    Armstrong, John R.
    Mosher, Benjamin D.
    [J]. NEUROHOSPITALIST, 2011, 1 (02) : 85 - 93
  • [3] Subclinical Atherosclerosis and Impaired Cardiac Autonomic Control in Pediatric Patients with Vitamin B12 Deficiency
    Celik, S. F.
    Celik, E.
    [J]. NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2018, 21 (08) : 1012 - 1016
  • [4] Intake of antioxidants and B vitamins is inversely associated with ischemic stroke and cerebral atherosclerosis
    Choe, Hansaem
    Hwang, Ji-Yun
    Yun, Jin A.
    Kim, Ji-Myung
    Song, Tae-Jin
    Chang, Namsoo
    Kim, Yong-Jae
    Kim, Yuri
    [J]. NUTRITION RESEARCH AND PRACTICE, 2016, 10 (05) : 516 - 523
  • [5] Sex-specific association of serum vitamin D levels with physical function in older adults
    Dam, T. -T. L.
    von Muehlen, D.
    Barrett-Connor, E. L.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2009, 20 (05) : 751 - 760
  • [6] Efficacy of Supplementation with B Vitamins for Stroke Prevention: A Network Meta-Analysis of Randomized Controlled Trials
    Dong, Hongli
    Pi, Fuhua
    Ding, Zan
    Chen, Wei
    Pang, Shaojie
    Dong, Wenya
    Zhang, Qingying
    [J]. PLOS ONE, 2015, 10 (09):
  • [7] Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction
    Faraci, FM
    Lentz, SR
    [J]. STROKE, 2004, 35 (02) : 345 - 347
  • [8] Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity
    Fenech, Michael
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2012, 733 (1-2) : 21 - 33
  • [9] Characteristics of patients with vitamin B12-responsive neuropathy: a case series with systematic repeated electrophysiological assessment
    Franques, Jerome
    Chiche, Laurent
    De Paula, Andre Maues
    Grapperon, Aude Marie
    Attarian, Shahram
    Pouget, Jean
    Mathis, Stephane
    [J]. NEUROLOGICAL RESEARCH, 2019, 41 (06) : 569 - 576
  • [10] Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B-12 metabolism
    Gueant, Jean-Louis
    Gueant-Rodriguez, Rosa-Maria
    Kosgei, Viola J.
    Coelho, David
    [J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2022, 57 (02) : 133 - 155