High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study

被引:0
作者
Schuckit, Marc A. [1 ]
Smith, Tom L. [1 ]
Mendoza, Lee Anne [1 ]
Danko, George [1 ]
Fisher, Hannah [1 ]
Laurance, Camarin [1 ]
机构
[1] Univ Calif San Diego Med Sch, Dept Psychiat, Sch Med, La Jolla, CA 92093 USA
来源
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH | 2025年 / 49卷 / 02期
关键词
alcohol response; alcohol use disorders; determinants; SEM; youth; HEAVY DRINKING; LOW-LEVEL; SOCIOECONOMIC-STATUS; UNITED-STATES; GENETIC RISK; MEN; MODEL; DEPENDENCE; INTERVENTION; PERSISTENCE;
D O I
10.1111/acer.15519
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
BackgroundPreliminary evaluations of 212 drinking offspring from the San Diego Prospective Study (SDPD) indicated that over 50% developed alcohol use disorder (AUD) by their mid-20s. The present analysis evaluated if those findings remained robust when the group increased to 454 individuals, a sample size that facilitated a search for potential contributors to the high AUD prevalence.MethodsSemistructured interviews were used to evaluate lifetime AUD diagnoses in 224 daughters and 230 sons from the SDPS (N = 454) by mean age 26. Analyses compared participants with and without AUD regarding demography, alcohol use, personality, and psychiatric diagnoses. Characteristics associated with AUD were entered together in a backward elimination regression analysis, and the results were entered in a structural equation model (SEM) to evaluate potential mediation of risks for alcohol problems.ResultsLifetime AUD was documented for 61% of the sons and 41% of the daughters. Offspring with AUD reported averages of 13 maximum and five usual drinks per occasion and endorsed an average of 4 DSM AUD criteria. Even after considering personality characteristics, family AUD histories, and personal psychiatric histories, significant contributions to the regression analysis were limited to lower levels of response to alcohol, higher positive alcohol expectancies, and drinking to cope. Key elements of the hypothesized SEM were supported, and mediation between the low alcohol response and the number of alcohol problems was documented for expectancies, drinking to cope, and peer heavier drinking.ConclusionThe results support prior high AUD rates in SDPS offspring and demonstrate that the AUD diagnoses were associated with robust alcohol intake and problems. The data also indicated mediation of the impact of the low alcohol response on the development of AUD through several characteristics proposed by prior work in other populations.
引用
收藏
页码:379 / 391
页数:13
相关论文
共 68 条
[1]  
American Psychiatric Association, 2022, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425596
[2]  
American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders, V5th, DOI 10.1176/appi.books.9780890425596
[3]   Relationship between level of response to alcohol and acute tolerance [J].
Anthenelli, Robert M. ;
McKenna, Benjamin S. ;
Smith, Tom L. ;
Schuckit, Marc A. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2021, 45 (07) :1504-1513
[4]  
Arbuckle J.A., 2003, AMOS 50 UPDATE AMOS
[5]  
Baraona E, 2001, ALCOHOL CLIN EXP RES, V25, P502, DOI 10.1097/00000374-200104000-00004
[6]   Alcohol and depression [J].
Boden, Joseph M. ;
Fergusson, David M. .
ADDICTION, 2011, 106 (05) :906-914
[7]   A NEW, SEMISTRUCTURED PSYCHIATRIC INTERVIEW FOR USE IN GENETIC-LINKAGE STUDIES - A REPORT ON THE RELIABILITY OF THE SSAGA [J].
BUCHOLZ, KK ;
CADORET, R ;
CLONINGER, CR ;
DINWIDDIE, SH ;
HESSELBROCK, VM ;
NURNBERGER, JI ;
REICH, T ;
SCHMIDT, I ;
SCHUCKIT, MA .
JOURNAL OF STUDIES ON ALCOHOL, 1994, 55 (02) :149-158
[8]   Socioeconomic status and alcohol use disorders across the lifespan: A co-relative control study [J].
Calling, Susanna ;
Ohlsson, Henrik ;
Sundquist, Jan ;
Sundquist, Kristina ;
Kendler, Kenneth S. .
PLOS ONE, 2019, 14 (10)
[9]   Growth, Persistence, and Desistance of Alcohol Use for At-Risk Men in Their 30s [J].
Capaldi, Deborah M. ;
Tiberio, Stacey S. ;
Washburn, Isaac J. ;
Yoerger, Karen ;
Feingold, Alan .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2015, 39 (07) :1203-1211
[10]   Long-Term Effects of a Personality-Targeted Intervention to Reduce Alcohol Use in Adolescents [J].
Conrod, Patricia J. ;
Castellanos-Ryan, Natalie ;
Mackie, Clare .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2011, 79 (03) :296-306