Investigating Dose Level and Duration of Rehabilitation of Mechanically Ventilated Patients in the ICU

被引：0

作者：

Watanabe, Shinichi ^{[1
,2
]}

Liu, Keibun ^{[3
]}

Hirota, Yoshie ^{[4
]}

Naito, Yuji ^{[5
]}

Sato, Naoya ^{[6
]}

Ishii, Shunsuke ^{[6
]}

Yano, Hiroyoshi ^{[6
,7
]}

Ogata, Ryota ^{[8
]}

Koyanagi, Yasuki ^{[9
]}

Yasumura, Daisetsu ^{[10
]}

Yamauchi, Kota ^{[11
]}

Suzuki, Keisuke

Katsukawa, Hajime ^{[12
]}

Morita, Yasunari ^{[13
]}

Eikermann, Matthias ^{[14
]}

机构：

[1] Natl Hosp Org, Nagoya Med Ctr, Dept Rehabil, Nagoya, Aichi, Japan

[2] Gifu Univ Hlth Sci, Fac Rehabil, Dept Phys Therapy, 2-92 Higashiuzura, Gifu 5008281, Japan

[3] Prince Charles Hosp, Crit Care Res Grp, Brisbane, Australia

[4] Natl Hosp Org, Beppu Med Ctr, Dept Rehabil, Oita, Japan

[5] Natl Hosp Org, Shizuoka Med Ctr, Dept Rehabil, Shizuoka, Japan

[6] Natl Hosp Org, Saitama Hosp, Dept Rehabil, Saitama, Japan

[7] Natl Hosp Org, Mito Med Ctr, Dept Rehabil, Ibaraki, Japan

[8] Natl Hosp Org, Hokkaido Med Ctr, Dept Rehabil Med, Sapporo, Hokkaido, Japan

[9] Natl Hosp Org, Sendai Med Ctr, Dept Rehabil Med, Sendai, Miyagi, Japan

[10] Naha City Hosp, Dept Gastroenterol, Naha, Okinawa, Japan

[11] Steel Mem Yawata Hosp, Dept Rehabil, Kitakyushu, Japan

[12] RIKEN AIP, Tokyo, Japan

[13] Nagoya Med Ctr, Natl Hosp Org, Dept Pharm, Nagoya, Aichi, Japan

[14] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Neurol, New York, NY USA

来源：

RESPIRATORY CARE | 2025年 / 70卷 / 03期

关键词：

ICU; rehabilitation; respiration; walking; critical care; early ambulation; CLINICAL-PRACTICE GUIDELINES; CRITICALLY-ILL PATIENTS; MOBILIZATION; DELIRIUM; THERAPY; MANAGEMENT;

D O I：

10.1089/respcare.12122

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: The dose level and duration needed for early rehabilitation of mechanically ventilated patients in the ICU need to be characterized. Therefore, this study aimed to assess the association between mobilization level, rehabilitation time, and dose (defined as the mean mobilization quantification score [MQS]) during ICU admission and the end point walking independence at hospital discharge in subjects needing ICU admission. Methods: This prospective, multi-center, cohort study included 9 ICUs. Consecutive subjects admitted to the ICU between September 2022-March 2023 receiving mechanical ventilation for >48 h were included in the study. The mean MQS score, highest ICU mobility score (IMS) during the ICU stay, time to the first mobilization day, ICU rehabilitation time (minutes of each rehabilitation physical activity from start to finish), frequency/d, baseline characteristics, and walking independence at hospital discharge were assessed. Results: Among the 116 subjects, 64 did and 51 did not walk independently at hospital discharge, respectively. Multiple logistic regression analysis revealed that the mean MQS and time to first mobilization were significantly associated with walking independence at hospital discharge. We observed that mean MQS was better than IMS, rehabilitation time, frequency, and time to first mobilization predicted walking independence based on receiver operating characteristic (ROC) curve comparison. Comparison of the mean MQS with that on the first mobilization day revealed superior predicting power of the mean MQS. The ROC curve cutoff value for the mean MQS was 4.0. Conclusions: This study shows that in subjects mechanically ventilated for >48 h the dose of rehabilitation calculated using the mean MQS during ICU was a better predictor of walking independence at hospital discharge than intensity, duration, or frequency of the mobilization therapy. Mean MQS during ICU stay may be used to measure and titrate optimal mobilization therapy.

引用

页码：278 / 286

页数：9