Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure

被引：0
作者：
Pantoja-Romero, Wenndy [1 ,2 ]
Aysa-Martinez, Yolanda [3 ]
Lavin-Flores, Alexis [1 ,2 ]
Medina-Berrios, Nataniel [1 ,2 ]
Bayro, Marvin J. [1 ,2 ]
Morell, Gerardo [2 ,4 ]
Weiner, Brad R. [1 ,2 ]
Coronas, Joaquin [3 ,5 ]
机构：
[1] Univ Puerto Rico, Dept Chem, Rio Piedras Campus,601 Av Univ, San Juan, PR USA
[2] Univ Puerto Rico, Mol Sci Res Ctr, Rio Piedras Campus,1390 C Juan, San Juan, PR 00926 USA
[3] Univ Zaragoza CSIC, Inst Nanociencia & Mat Aragon INMA, Zaragoza 50018, Spain
[4] Univ Puerto Rico, Dept Phys, Rio Piedras Campus,601 Av Univ, San Juan, PR USA
[5] Univ Zaragoza, Chem & Environm Engn Dept, Zaragoza 50018, Spain
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2024年 / 27卷 / 36期
基金：
美国国家卫生研究院;
关键词：
Metal-organic frameworks; Organic-inorganic hybrid composites; High-pressure chemistry; ZIF-8; NANOSPHERES; ANTICANCER; MIL-53(AL); CRYSTALS; CAFFEINE;
D O I：
10.1002/ejic.202400511
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Andrographolide (ADG) encapsulation was carried out on MOFs MIL-53(Al) and ZIF-8 by high-pressure (0.3 GPa) contact. This methodology is not only environment-friendly but also energy/time-saving and gives rise to ADG-MOFs with physical features equivalent to those of materials obtained by common liquid phase encapsulation. The loaded MOFs were characterized through TEM, SEM, XRD, TGA, FT-IR, BET, and NMR. The observed decrease in the intensity of ADG XRD peaks is due to the adsorption of ADG into the MOFs. TGA showed the decomposition step of ADG in the range of 200-300 degrees C in both loaded MOFs. FT-IR also showed intense signals of the ADG in the synthesized materials. The dissolution profile of ADG in MIL-53(Al) in PBS (pH=7.4) was carried out showing that the drug was released up to 96 % after 75 h. Solid-state NMR confirmed the interactions between ADG molecules and ZIF-8 groups and the formation of a hydrogen bond between the carboxylic group of ADG and the hydroxyl group of MIL-53(Al). Coefficient partition studies determined that both MOFs did not improve the hydrophilicity of the ADG, due to the loading of the drug preferably occurring by interactions in the hydrophobic areas within the pores of the MOFs.
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页数：8
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