The Impact of Polydimethylsiloxane (PDMS) in Engineering: Recent Advances and Applications

被引:1
作者
Lima, Rui A. [1 ,2 ,3 ]
机构
[1] Univ Minho, Mech Engn Dept, MEtRICs, Campus Azurem, P-4800058 Guimaraes, Portugal
[2] Univ Porto, Fac Engn, CEFT Transport Phenomena Res Ctr, Rua Dr Roberto Frias, P-4200465 Porto, Portugal
[3] Univ Porto, Fac Engn, ALiCE Associate Lab Chem Engn, Rua Dr Roberto Frias, P-4200465 Porto, Portugal
关键词
polydimethylsiloxane; PDMS applications; microfluidics; blood flow; PDMS masks; biomedical engineering; surface modification; RED-BLOOD-CELL; ERYTHROCYTE DEFORMABILITY; HYDROPHOBIC RECOVERY; THERMAL-CONDUCTIVITY; MICROFLUIDIC DEVICES; SURFACE MODIFICATION; FLOW; POLY(DIMETHYLSILOXANE); MODEL; FABRICATION;
D O I
10.3390/fluids10020041
中图分类号
O3 [力学];
学科分类号
08 ; 0801 ;
摘要
Since the introduction of polydimethylsiloxane (PDMS) microfluidic devices at the beginning of the 21st century, this elastomeric polymer has gained significant attention in the engineering community due to its biocompatibility, exceptional mechanical and optical properties, thermal stability, and versatility. PDMS has been widely used for in vitro experiments ranging from the macro- to nanoscale, enabling advances in blood flow studies, biomodels improvement, and numerical validations. PDMS devices, including microfluidic systems, have been employed to investigate different kinds of fluids and flow phenomena such as in vitro blood flow, blood analogues, the deformation of individual cells and the cell free layer (CFL). The most recent applications of PDMS involve complex hemodynamic studies such as flow in aneurysms and in organ-on-a-chip (OoC) platforms. Furthermore, the distinctive properties of PDMS, including optical transparency, thermal stability, and versality have inspired innovative applications beyond biomedical applications, such as the development of transparent, virus-protective face masks, including those for SARS-CoV-2 and serpentine heat exchangers to enhance heat transfer and energy efficiency in different kinds of thermal systems. This review provides a comprehensive overview of the current research performed with PDMS and outlines some future directions, in particular applications of PDMS in engineering, including biomicrofluidics, in vitro biomodels, heat transfer, and face masks. Additionally, challenges related to PDMS hydrophobicity, molecule absorption, and long-term stability are discussed alongside the solutions proposed in the most recent research studies.
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页数:24
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  • [1] Wolf M.P., Salieb-Beugelaar G.B., Hunziker P., PDMS with designer functionalities—Properties, modifications strategies, and applications, Prog. Polym. Sci, 83, pp. 97-134, (2018)
  • [2] Sackmann E.K., Fulton A.L., Beebe D.J., The present and future role of microfluidics in biomedical research, Nature, 507, pp. 181-189, (2014)
  • [3] Fallahi H., Zhang J., Phan H.-P., Nguyen N.-T., Flexible Microfluidics: Fundamentals, Recent Developments, and Applications, Micromachines, 10, (2019)
  • [4] Salieb-Beugelaar G.B., Simone G., Arora A., Philippi A., Manz A., Latest developments in microfluidic cell biology and analysis systems, Anal. Chem, 82, pp. 4848-4864, (2010)
  • [5] Souza A., Nobrega G., Neves L.B., Barbosa F., Ribeiro J., Ferrera C., Lima R.A., Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications, Micromachines, 15, (2024)
  • [6] Clarson S.J., Dodgson K., Semlyen J.A., Studies of Cyclic and Linear Poly(Dimethylsiloxanes): 19. Glass-Transition Temperatures and Crystallization Behavior, Polymer, 26, pp. 930-934, (1985)
  • [7] Ruzi M., Celik N., Onses M.S., Superhydrophobic Coatings for Food Packaging Applications: A Review, Food Packag. Shelf Life, 32, (2022)
  • [8] Zhou J., Khodakov D.A., Ellis A.V., Voelcker N.H., Surface Modification for PDMS-Based Microfluidic Devices, Electrophoresis, 33, pp. 89-104, (2012)
  • [9] van Poll M.L., Zhou F., Ramstedt M., Hu L., Huck W.T.S., A Self-Assembly Approach to Chemical Micropatterning of Poly(Dimethylsiloxane), Angew. Chem, 119, pp. 6754-6757, (2007)
  • [10] Merkel T.C., Bondar V.I., Nagai K., Freeman B.D., Pinnau I., Gas Sorption, Diffusion, and Permeation in Poly(Dimethylsiloxane), J. Polym. Sci. B Polym. Phys, 38, pp. 415-434, (2000)