Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery

被引：0
作者：
Erickson, Nicholas J. [1 ]
Stavarache, Mihaela [2 ]
Tekedereli, Ibrahim [1 ]
Kaplitt, Michael G. [2 ]
Markert, James M. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35294 USA
[2] Weill Cornell Med, Dept Neurol Surg, Lab Mol Neurosurg, New York, NY USA
来源：
WORLD NEUROSURGERY | 2025年 / 194卷
关键词：
Magnetic resonance-guided focused ultrasound; Magnetic Malignant glioma; Oncolytic viral therapy; INTENSITY FOCUSED ULTRASOUND; BRAIN-BARRIER DISRUPTION; LIPOSOMAL DOXORUBICIN; RIBONUCLEOTIDE REDUCTASE; GLIOBLASTOMA-MULTIFORME; ENHANCED DELIVERY; TUMOR BARRIER; VIRUS; REPLICATION; VIROTHERAPY;
D O I：
10.1016/j.wneu.2024.123595
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
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页数：9
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