Pathophysiology of Prurigo Nodularis: Neuroimmune Dysregulation and the Role of Type 2 Inflammation

被引：0
作者：
Kwatra, Shawn G. [1 ,2 ]
Staender, Sonja [3 ,4 ]
Yosipovitch, Gil [5 ]
Kim, Brian S. [6 ]
Levit, Noah A. [7 ]
O'Malley, John T. [8 ]
机构：
[1] Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD USA
[2] Univ Maryland, Sch Med, Maryland Itch Ctr, Baltimore, MD USA
[3] Univ Hosp Munster, Dept Dermatol, Munster, Germany
[4] Univ Hosp Munster, Ctr Chron Pruritus, Munster, Germany
[5] Univ Miami, Miami Itch Ctr, Dr Philip Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA
[6] Icahn Sch Med Mt Sinai, Mark Lebwohl Ctr Neuroinflammat & Sensat, Dept Dermatol, New York, NY USA
[7] Dermatol Phys Connecticut, Fairfield, CT USA
[8] Sanofi, 450 Water St, Cambridge, MA 02141 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2025年 / 145卷 / 02期
关键词：
Neuroimmune axis; Pathophysiology; Prurigo nodularis; Type; 2; immunity; NERVE GROWTH-FACTOR; IMMUNOREACTIVE NERVES; TRIAL; PATHOGENESIS; NEMOLIZUMAB; EXPLORATION; BURDEN; ITCH; SKIN;
D O I：
10.1016/j.jid.2024.06.1276
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Prurigo nodularis (PN) is a chronic, inflammatory skin condition characterized by multiple, intensely pruritic, distinctive nodular lesions. Subsequent scratching can further intensify the pruritus, culminating in a self-reinforcing itch-scratch cycle, which drives lesion development. The latest data indicate dysregulation of the neuroimmune axis in PN pathogenesis, including the involvement of sensory neurons, key effector immune cells, proinflammatory cytokines, dermal fibroblasts, and pruritogens. In this review, we highlight evidence supporting the role of type 2 immune axis dysregulation in driving the clinical presentation of PN and discuss how related signaling pathways may offer effective therapeutic targets to control PN signs and symptoms.
引用
收藏
页码：249 / 256
页数：8
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