Intrinsically Disordered Regions of.-synuclein Fibrils Play a Critical Role in Aggregation Inhibition

被引:0
|
作者
Chinchilla, Priscilla [1 ]
Wang, Baifan [2 ,3 ]
Yang, Xue [4 ]
Roth, Jonathan [1 ]
Khare, Sagar D. [1 ]
Baum, Jean [1 ]
机构
[1] Rutgers State Univ, Chem & Chem Biol, New Brunswick, NJ USA
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin, Peoples R China
[3] Nankai Univ, Dept Chem Biol, Tianjin, Peoples R China
[4] AbbVie, Biores Ctr, N Chicago, IL 60064 USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
W51
引用
收藏
页码:137 / 138
页数:2
相关论文
共 50 条
  • [31] Structural Insights into ATP-Sensitive Potassium Channel Mechanics: A Role of Intrinsically Disordered Regions
    Walczewska-Szewc, Katarzyna
    Nowak, Wieslaw
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 63 (06) : 1806 - 1818
  • [32] Role of intrinsically disordered regions of promyelocytic leukemia (PML) protein in the formation of PML-bodies
    Fefilova, A.
    Fonin, A.
    Silonov, S.
    Stepananeko, O.
    Gavrilova, A.
    Kuznetsova, I.
    Turoverov, K.
    FEBS OPEN BIO, 2022, 12 : 73 - 73
  • [33] "Structure"-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation
    Ferrie, John J.
    Karr, Jonathan P.
    Tjian, Robert
    Darzacq, Xavier
    MOLECULAR CELL, 2022, 82 (21) : 3970 - 3984
  • [34] Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation
    Goretzki, Benedikt
    Guhl, Charlotte
    Tebbe, Frederike
    Harder, Jean-Martin
    Hellmich, Ute A.
    JOURNAL OF MOLECULAR BIOLOGY, 2021, 433 (17)
  • [35] A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions
    Frieden, Carl
    Wang, Hanliu
    Ho, Chris M. W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (24) : 6292 - 6297
  • [36] Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV-1 Rev Protein
    Faust, Ofrah
    Grunhaus, Dana
    Shimshon, Odelia
    Yavin, Eylon
    Friedler, Assaf
    CHEMBIOCHEM, 2018, 19 (15) : 1618 - 1624
  • [37] The intrinsically disordered frequency isoforms of Neurospora crassa play a dynamic role in negative arm circadian clock regulation
    Pelham, Jacqueline
    Thomas, Joshua
    Mosier, Alexander E.
    Rhodes, Morgan L.
    Holehouse, Alex S.
    Hurley, Jennifer M.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 300A - 301A
  • [38] Probing the Role of Disordered N- and C-Terminal Regions During α-Synuclein Fibril Assembly
    Yap, Thai L.
    Pfefferkorn, Candace Marie
    Lee, Jennifer Chen
    BIOPHYSICAL JOURNAL, 2011, 100 (03) : 60 - 60
  • [39] Novel Disease Variants Reveal Critical Functions for Intrinsically Disordered Regions Encoded by the Diabetes Gene CLEC16A
    Gingerich, Morgan
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 215A - 215A
  • [40] A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation
    Dettori, Leonardo G.
    Torrejon, Diego
    Chakraborty, Arijita
    Dutta, Arijit
    Mohamed, Mohamed
    Papp, Csaba
    Kuznetsov, Vladimir A.
    Sung, Patrick
    Feng, Wenyi
    Bah, Alaji
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8