NEK kinases in cell cycle regulation, DNA damage response, and cancer progression

被引：2

作者：

Folahan, Joy T. ^{[1
]}

Barabutis, Nektarios ^{[1
]}

机构：

[1] Univ Louisiana Monroe, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, 1800 Bienville Dr, Monroe, LA 71201 USA

来源：

TISSUE & CELL | 2025年 / 94卷

基金：

美国国家卫生研究院;

关键词：

Mitosis; Replication stress; Genomic instability; NIMA-RELATED KINASES; PROTEIN-KINASE; MITOCHONDRIAL DYSFUNCTION; CHECKPOINT CONTROL; SPINDLE FORMATION; BETA-CATENIN; MITOSIS GENE; REPLICATION; PHOSPHORYLATION; ACTIVATION;

D O I：

10.1016/j.tice.2025.102811

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The NIMA-related kinase (NEK) family of serine/threonine kinases is essential for the regulation of cell cycle progression, mitotic spindle assembly, and genomic stability. In this review, we explore the structural and functional diversity of NEK kinases, highlighting their roles in both canonical and non-canonical cellular processes. We examine recent preclinical findings on NEK inhibition, showcasing promising results for NEK-targeted therapies, particularly in cancer types characterized by high NEK expression. We discussed the therapeutic potential of targeting NEKs as modulators of cell cycle and DDR pathways, with a focus on identifying strategies to exploit NEK activity for enhanced treatment efficacy. Future research directions are proposed to further elucidate NEK-mediated mechanisms and to develop selective inhibitors that target NEK-related pathways.

引用

页数：11

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