Current Perspective and Mechanistic Insights on α-Hederin for the Prevention and Treatment of Several Noncommunicable Diseases

被引:2
作者
El-Shiekh, Riham A. [1 ]
Atwa, Ahmed M. [2 ,3 ]
Elgindy, Ali M. [2 ]
Ibrahim, Kawther Magdy [2 ]
Senna, Mohamed Magdy [2 ]
Ebid, Nouran [2 ]
Mustafa, Aya M. [2 ]
机构
[1] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt
[2] Egyptian Russian Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt
[3] Al Ayen Iraqi Univ, Coll Pharm, Dept Pharmacol & Toxicol, Thi Qar, Iraq
关键词
drug discovery; pharmacological activities; saponins; alpha-hederin; NIGELLA-SATIVA; IN-VITRO; NEURODEGENERATIVE DISEASES; TRITERPENOID SAPONINS; ACTIVE CONSTITUENT; HEDERACOLCHISIDE-E; OXIDATIVE STRESS; HEDERASAPONIN-C; MESSENGER-RNA; CANCER;
D O I
10.1002/cbdv.202402289
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
alpha-Hederin, a naturally occurring compound found in various plant sources, has remarkable properties and therapeutic potential for human health. One notable attribute is its potent anti-inflammatory activity, such as in arthritis, asthma, and inflammatory bowel disease. In addition, it exhibits notable antioxidant effects implicated in the development of chronic diseases, including cardiovascular disorders and certain types of cancer. According to research, it may limit the growth and proliferation of cancer cells, making it a possible candidate for future cancer treatments. Moreover, it is a promising neuroprotective agent and enhances cognitive function, suggesting its potential in the treatment of neurodegenerative illnesses like Alzheimer's and Parkinson's disease. The multifaceted benefits of alpha-hederin make it an intriguing compound with significant therapeutic implications. As research progresses, exploring its mechanisms of action and clinical applications is warranted. Harnessing the potential of alpha-hederin may pave the way for innovative treatment strategies and improved outcomes in the battle against various chronic diseases.
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页数:14
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