Considerations for the Use of Stereotactic Radiosurgery to Treat Large Arteriovenous Malformations

被引:2
作者
Lim, Jong Hyun [1 ]
Kim, Myung Ji [1 ]
机构
[1] Korea Univ, Korea Univ Ansan Hosp, Dept Neurosurg, Coll Med, 123 Jeokgeum Ro, Ansan 15355, Gyeonggi Do, South Korea
关键词
arteriovenous malformation (AVM); stereotactic radiosurgery (SRS); gamma knife radiosurgery; adverse radiation effect (ARE); radiation-induced change (RIC); volume-staged; dose-staged; obliteration; intracranial hemorrhage; large-volume; GAMMA-KNIFE SURGERY; TERM-FOLLOW-UP; STAGED-VOLUME RADIOSURGERY; SPETZLER-MARTIN GRADE; NATURAL-HISTORY; OCCLUSIVE HYPEREMIA; RANDOMIZED-TRIAL; HEMORRHAGE RISK; DOSE-RESPONSE; BRAIN;
D O I
10.3390/biomedicines12092003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stereotactic radiosurgery (SRS) is an effective treatment strategy for cerebral arteriovenous malformations (AVMs). Aggressive treatment achieving complete obliteration is necessary to prevent further intracranial hemorrhage and neurological deficits. However, SRS treatment of large AVMs (>10 cm(3)) is challenging. To prevent toxicity in the normal brain tissue, it is imperative to reduce the radiation dose as the lesion volume increases; however, this also reduces the rate of obliteration. In this study, we review the various radiosurgical approaches for treating large AVMs and their outcomes, and suggest ways to improve treatment outcomes during SRS for large AVMs.
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页数:16
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