Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis

被引：1

作者：

Khan, Muhammad Zahoor ^{[1
]}

Li, Liangliang ^{[1
]}

Zhan, Yandong ^{[1
]}

Huang, Binjiang ^{[1
]}

Liu, Xiaotong ^{[1
]}

Kou, Xiyan ^{[1
]}

Khan, Adnan ^{[2
]}

Qadeer, Abdul ^{[3
]}

Ullah, Qudrat ^{[4
]}

Alzahrani, Khalid J. ^{[5
]}

Wang, Tongtong ^{[1
]}

Wang, Changfa ^{[1
]}

Zahoor, Muhammad ^{[6
]}

机构：

[1] Liaocheng Univ, Liaocheng Res Inst Donkey High Efficiency Breeding, Liaocheng, Peoples R China

[2] Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Genome Anal Lab, Minist Agr, Shenzhen, Peoples R China

[3] Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha, Peoples R China

[4] Cholistan Univ Vet & Anim Sci, Fac Vet & Anim Sci, Dept Theriogenol, Bahawalpur, Punjab, Pakistan

[5] Taif Univ, Coll Appl Med Sci, Dept Clin Labs Sci, Taif, Saudi Arabia

[6] Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Oslo, Norway

来源：

FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

mastitis; inflammation; immunity; oxidative stress; antioxidants; bioactive compounds; Nrf2/Keap1 signaling pathway; MAMMARY EPITHELIAL-CELLS; NF-KAPPA-B; NONESTERIFIED FATTY-ACIDS; INDUCED OXIDATIVE STRESS; INFLAMMATORY RESPONSES; NRF2; ACTIVATION; BOVINE; PROTECTS; DISEASE; MILKING;

D O I：

10.3389/fimmu.2025.1425901

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. The Nrf2/KEAP1 signaling pathway plays a critical role in regulating antioxidant responses and cellular defense mechanisms. When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. Here, we summarize recent studies to highlight the therapeutic potential of Nrf2/KEAP1 pathway in the prevention and treatment of mastitis. Collectively this review article aims to explore the potential of bioactive compounds in mitigating mastitis by targeting the Nrf2/KEAP1 signaling pathway.

引用

页数：18

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