Recent Web Platforms for Multi-Omics Integration Unlocking Biological Complexity

被引:0
作者
Papadaki, Eugenia [1 ,3 ]
Kakkos, Ioannis [2 ,4 ]
Vlamos, Panagiotis [1 ,3 ]
Petropoulou, Ourania [2 ]
Miloulis, Stavros T. [2 ]
Palamas, Stergios [3 ]
Vrahatis, Aristidis G. [1 ,3 ]
机构
[1] Ionian Univ, Dept Informat, Bioinformat & Human Electrophysiol Lab, Corfu 49100, Greece
[2] Natl Tech Univ Athens, Sch Elect & Comp Engn, Biomed Engn Lab, 9,Iroon Polytech St, Athens 15780, Greece
[3] Ionian Univ, Dept Informat, Corfu 49100, Greece
[4] Univ West Attica, Dept Biomed Engn, Athens 12243, Greece
来源
APPLIED SCIENCES-BASEL | 2025年 / 15卷 / 01期
关键词
multi-omics data integration; digital healthcare platforms; genomics; epigenomics; metabolomics; personalized medicine; AI in healthcare; comprehensive healthcare; omics inter-operability; digital tools in healthcare; data standardization; machine learning in omics;
D O I
10.3390/app15010329
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The rapid advancement of high-throughput technologies has led to the generation of vast amounts of omics data, including genomics, epigenomics, and metabolomics. Integrating these diverse datasets has become essential for gaining comprehensive insights into complex biological systems and enhancing personalized healthcare solutions. This critical review examines the current state of multi-omics data integration platforms, highlighting both the strengths and limitations of existing tools. By evaluating the latest digital platforms, such as GraphOmics, OmicsAnalyst, and others, the paper explores how they support seamless integration and analysis of omics data in healthcare applications. Special attention is given to their role in clinical decision-making, disease prediction, and personalized medicine, with a focus on their interoperability, scalability, and usability. The review also discusses the challenges these platforms face, such as data complexity, standardization issues, and the need for improved machine learning and AI-based analytics. Finally, the paper proposes directions for future research and development, emphasizing the importance of more advanced, user-friendly, and secure platforms that can better serve comprehensive healthcare needs.
引用
收藏
页数:21
相关论文
共 50 条
  • [31] Knowledge Base Commons (KBCommons) v1.1: a universal framework for multi-omics data integration and biological discoveries
    Shuai Zeng
    Zhen Lyu
    Siva Ratna Kumari Narisetti
    Dong Xu
    Trupti Joshi
    BMC Genomics, 20
  • [32] Knowledge Base Commons (KBCommons) v1.1: a universal framework for multi-omics data integration and biological discoveries
    Zeng, Shuai
    Lyu, Zhen
    Narisetti, Siva Ratna Kumari
    Xu, Dong
    Joshi, Trupti
    BMC GENOMICS, 2019, 20 (Suppl 11)
  • [33] Multi-omics enrichment analysis using the GeneTrail2 web service
    Stoeckel, Daniel
    Kehl, Tim
    Trampert, Patrick
    Schneider, Lara
    Backes, Christina
    Ludwig, Nicole
    Gerasch, Andreas
    Kaufmann, Michael
    Gessler, Manfred
    Graf, Norbert
    Meese, Eckart
    Keller, Andreas
    Lenhof, Hans-Peter
    BIOINFORMATICS, 2016, 32 (10) : 1502 - 1508
  • [34] Progress in single-cell multimodal sequencing and multi-omics data integration
    Wang, Xuefei
    Wu, Xinchao
    Hong, Ni
    Jin, Wenfei
    BIOPHYSICAL REVIEWS, 2024, 16 (01) : 13 - 28
  • [35] The World of Cave Microbiomes: Biodiversity, Ecological Interactions, Chemistry, and the Multi-Omics Integration
    Kato, Natalia N.
    Arini, Gabriel S.
    Silva, Ricardo Roberto
    Bichuette, Maria Elina
    Bitencourt, Jose Augusto P.
    Lopes, Norberto P.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2023,
  • [36] Multi-omics Data Integration Model based on Isomap and Convolutional Neural Network
    Alkhateeb, Abedalrhman
    ElKarami, Bashier
    Qattous, Hazem
    Al-refai, Abdullah
    AlAfeshat, Noor
    Shahrrava, Behnam
    Azzeh, Mohammad
    2022 21ST IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS, ICMLA, 2022, : 1381 - 1385
  • [37] A Concise Review on Multi-Omics Data Integration for Terroir Analysis in Vitis vinifera
    Fabres, Pastor Jullian
    Collins, Cassandra
    Cavagnaro, Timothy R.
    Lopez, Carlos M. Rodriguez
    FRONTIERS IN PLANT SCIENCE, 2017, 8
  • [38] Progress in single-cell multimodal sequencing and multi-omics data integration
    Xuefei Wang
    Xinchao Wu
    Ni Hong
    Wenfei Jin
    Biophysical Reviews, 2024, 16 : 13 - 28
  • [39] MDICC: novel method for multi-omics data integration and cancer subtype identification
    Yang, Ying
    Tian, Sha
    Qiu, Yushan
    Zhao, Pu
    Zou, Quan
    BRIEFINGS IN BIOINFORMATICS, 2022, 23 (03)
  • [40] Multi-omics integration reveals a nonlinear signature that precedes progression of lung fibrosis
    Pattaroni, Celine
    Begka, Christina
    Cardwell, Bailey
    Jaffar, Jade
    Macowan, Matthew
    Harris, Nicola L.
    Westall, Glen P.
    Marsland, Benjamin J.
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2024, 13 (01)