Effects of extracorporeal photopheresis on survival in chronic graft versus host disease

被引：0

作者：

Kaya, Ahmet ^{[1
]}

Kaya, Emin ^{[1
]}

Kuku, Irfan ^{[1
]}

Erkurt, Mehmet Ali ^{[1
]}

Berber, Ilhami ^{[1
]}

Bicim, Soykan ^{[1
]}

Arslan, Suleymen ^{[1
]}

Yagin, Fatma Hilal ^{[2
]}

Uysal, Ayse ^{[3
]}

机构：

[1] Inonu Univ, Fac Med, Turgut Ozal Med Ctr, Dept Internal Med,Div Hematol, Malatya, Turkiye

[2] Inonu Univ, Fac Med, Dept Biostat & Med Informat, Malatya, Turkiye

[3] Firat Univ, Fac Med, Dept Internal Med, Div Hematol, Elazig, Turkiye

来源：

MARMARA MEDICAL JOURNAL | 2024年 / 37卷 / 03期

关键词：

Graft versus host disease; Allogeneic hematopoietic cell transplantation; Extracorporeal photopheresis; Survival; CONSENSUS DEVELOPMENT PROJECT; CLINICAL-TRIALS; DIAGNOSIS; CRITERIA;

D O I：

10.5472/marumj.1573775

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Chronic graft versus host disease (cGVHD) develops after allogeneic hematopoietic cell transplantation, when immune cells from a non-identical donor initiate an immune reaction against the transplant recipient. Extracorporeal photopheresis (ECP) can be used in combination with prednisone in steroid-resistant cGVHD. In this study, the effect of ECP use on survival in cGVHD was examined. Patients and Methods: Twenty-six patients who were followed up in the adult Hematology Clinic of Inonu University Turgut Ozal Medical Center for cGVHD were included in the study. Stem cell transplantation and ECP application parameters that may affect the survival of the patients were examined. Results: The degree of involvement in cGVHD affects survival. Involvements with clinical and laboratory scores of 2 and above according to the National Institutes of Health consensus criteria, significantly reduced survival. The development time of cGVHD was found to be associated with survival, and that it had a positive impact on survival, especially when the disease developed after 220 days after the transplantation. It was observed that steroid dose taken during ECP, patient age and cGVHD prophylaxis used affected survival. Conclusion: The use of ECP may be effective in survival, especially, in patients who develop cGVHD, 220 days after allogeneic transplantation. Concurrent use of steroids with ECP affects survival.

引用

页码：358 / 365

页数：8

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