The Effect of a Life-Stage Based Intervention on Depression in Youth Living with HIV in Kenya and Uganda: Results from the SEARCH-Youth Trial

被引：0

作者：

Mwangwa, Florence ^{[1
]}

Johnson-Peretz, Jason ^{[2
]}

Peng, James ^{[3
]}

Balzer, Laura B. ^{[4
]}

Litunya, Janice ^{[5
]}

Nakigudde, Janet ^{[6
]}

Black, Douglas ^{[2
]}

Owino, Lawrence ^{[7
]}

Akatukwasa, Cecilia ^{[1
]}

Onyango, Anjeline ^{[7
]}

Atwine, Fredrick ^{[1
]}

Arunga, Titus O. ^{[7
]}

Ayieko, James ^{[5
]}

Kamya, Moses R. ^{[1
,6
]}

Havlir, Diane ^{[2
]}

Camlin, Carol S. ^{[2
]}

Ruel, Theodore ^{[2
]}

机构：

[1] Infect Dis Res Collaborat, POB 7074, Kampala, Uganda

[2] Univ Calif San Francisco, San Francisco, CA 94158 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[4] Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, Berkeley, CA 94720 USA

[5] Kenya Govt Med Res Ctr, POB 517-20107, Njoro, Kenya

[6] Makerere Univ, Dept Psychiat, Coll Hlth Sci, POB 7072, Kampala, Uganda

[7] Kenya Govt Med Res Ctr, POB 614-40100, Kisumu, Kenya

来源：

TROPICAL MEDICINE AND INFECTIOUS DISEASE | 2025年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

depression; HIV; young adults; adolescents; sub-Saharan Africa; MENTAL-HEALTH; SEXUAL-ABUSE; ADOLESCENTS; CHILDREN; VIOLENCE; ADHERENCE; AFRICA; WOMEN; CARE;

D O I：

10.3390/tropicalmed10020055

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Depression among adolescents and young adults with HIV affects both their wellbeing and clinical care outcomes. Integrated care models are needed. We hypothesized that the SEARCH-Youth intervention, a life-stage-based care model that improved viral suppression, would reduce depressive symptoms as compared to the standard of care. We conducted a mixed-methods study of youth with HIV aged 15-24 years in SEARCH-Youth, a cluster-randomized trial in rural Uganda and Kenya (NCT03848728). Depression was assessed cross-sectionally with the PHQ-9 screening tool and compared by arm using targeted minimum loss-based estimation. In-depth semi-structured interviews with young participants, family members, and providers were analyzed using a modified framework of select codes pertaining to depression. We surveyed 1,234 participants (median age 21 years, 80% female). Having any depressive symptoms was less common in the intervention arm (53%) compared to the control (73%), representing a 28% risk reduction (risk ratio: 0.72; CI: 0.59-0.89). Predictors of at least mild depression included pressure to have sex, physical threats, and recent major life events. Longitudinal qualitative research among 113 participants found that supportive counseling from providers helped patients build confidence and coping skills. Integrated models of care that address social threats, adverse life events, and social support can be used to reduce depression among adolescents and young adults with HIV.

引用

页数：24

共 57 条

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