Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis

被引：0

作者：

Hirose, Kazutoshi ^{[1
]}

Kiriyama, Hiroyuki ^{[1
]}

Minatsuki, Shun ^{[1
]}

Nagae, Yugo ^{[1
,2
,3
]}

Furusawa, Tatsuki ^{[1
]}

Hiruma, Takashi ^{[1
]}

Kobayashi, Atsushi ^{[1
]}

Sato, Masataka ^{[1
]}

Sawano, Shinnosuke ^{[1
]}

Kamon, Tatsuya ^{[1
]}

Shinohara, Hiroki ^{[1
]}

Miura, Mizuki ^{[1
]}

Saito, Akihito ^{[1
]}

Kodera, Satoshi ^{[1
]}

Ishida, Junichi ^{[1
]}

Takeda, Norifumi ^{[1
]}

Morita, Hiroyuki ^{[1
]}

Komuro, Issei ^{[1
,4
,5
]}

Takeda, Norihiko ^{[1
]}

机构：

[1] Univ Tokyo, Dept Cardiovasc Med, Tokyo, Japan

[2] Univ Tokyo, Dept Healthcare Informat Syst, Tokyo, Japan

[3] Kitasato Univ, Grad Sch Med Sci, Dept Med Safety Engn, Sagamihara, Kanagawa, Japan

[4] Univ Tokyo, Dept Frontier Cardiovasc Sci, Tokyo, Japan

[5] Int Univ Hlth & Welf, Tokyo, Japan

来源：

IJC HEART & VASCULATURE | 2025年 / 57卷

关键词：

Cardiovascular outcome; Systemic sclerosis; Coronary artery disease; Percutaneous coronary intervention; VENTRICULAR DIASTOLIC FUNCTION; RISK-FACTORS; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; ARTERY-DISEASE; HEART-DISEASE; MORTALITY; ECHOCARDIOGRAPHY; ATHEROSCLEROSIS; RECOMMENDATIONS;

D O I：

10.1016/j.ijcha.2025.101625

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Recent data have shown that systemic sclerosis (SSc) is a significant risk factor for coronary artery disease (CAD) and poorer cardiovascular outcomes in the setting of acute coronary syndrome. However, the morphological characteristics of CAD and the long-term cardiovascular outcomes in patients with concurrent SSc and CAD remain unclear. Methods: We retrospectively investigated 3,300 patients with CAD who underwent percutaneous coronary intervention (PCI) without prior myocardial infarction or coronary artery revascularization. Laboratory, echocardiographic and angiographic characteristics, and clinical outcomes were compared between patients with and without SSc according to a 1:3 propensity score-matching analysis adjusted for patient demographics and comorbidities. The primary outcome was a composite of cardiac death, myocardial infarction, and stroke, and the secondary outcome was a composite of the primary outcome and heart failure hospitalization. Results: Among all 3,300 patients, 17 (0.5 %) had SSc. The patients were classified into an SSc group (n = 17) and non-SSc group (n = 51) by propensity score matching. There were no significant differences in laboratory or echocardiographic parameters between the two groups. However, CAD tended to be more complex in the SSc group because of the higher proportion of left main trunk lesions (p = 0.100) and higher SYNergy between PCI with TAXUSTM and Cardiac Surgery (SYNTAX) score (p = 0.030). During a median follow-up of 3.1 years, patients with SSc more frequently experienced primary and secondary outcomes than those without SSc (both logrank p < 0.02). Conclusions: Among patients with CAD, long-term cardiovascular outcomes after PCI were poorer in those with than without SSc.

引用

页数：7

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[1] A qualitative systematic review of the prevalence of coronary artery disease in systemic sclerosis [J].