Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity

被引：0
|
作者：
Chen, Ruina [1 ]
Cheng, Jingru [1 ]
Pan, Hongqiu [2 ]
Lu, Lihuan [3 ]
He, Xiaomin [4 ]
Zhang, Meiling [5 ]
Yi, Honggang [1 ]
Tang, Shaowen [1 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Peoples R China
[2] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept TB, Zhenjiang, Peoples R China
[3] Second Peoples Hosp Changshu, Dept TB, Suzhou, Changshu, Peoples R China
[4] Peoples Hosp Taixing, Dept Infect Dis, Taixing, Peoples R China
[5] Jiangsu Univ, Jurong Hosp, Dept Infect Dis, Zhenjiang, Peoples R China
来源：
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | 2025年 / 34卷 / 01期
基金：
中国国家自然科学基金;
关键词：
antituberculosis drug-induced hepatotoxicity; ATP-binding cassette B6; ABCB6; genetic polymorphisms; case; control study; PROTOPORPHYRIN IX ACCUMULATION; INDUCED LIVER-INJURY; PATHOGENESIS; GUIDELINES;
D O I：
10.15403/jgld-5892
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background & Aims: The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH). Methods: A 1:4 matched case-control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison. Results: 224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls. Conclusions: SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.
引用
收藏
页码：55 / 63
页数：9
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