Selenium and Episodic Memory: The Moderating Role of Apolipoprotein E ε4

被引:2
作者
Kim, Shin Gyeom [1 ]
Keum, Musung [2 ]
Choe, Young Min [2 ,3 ]
Suh, Guk-Hee [2 ,3 ]
Lee, Boung Chul [3 ,4 ]
Kim, Hyun Soo [5 ]
Lee, Jun Hyung [6 ]
Hwang, Jaeuk [7 ]
Yi, Dahyun [8 ]
Kim, Jee Wook [2 ,3 ]
机构
[1] Soonchunhyang Univ, Bucheon Hosp, Bucheon Hosp, Bucheon 14584, South Korea
[2] Hallym Univ, Dongtan Sacred Heart Hosp, Dongtan Sacred Heart Hosp, Hwaseong, Gyeonggi, South Korea
[3] Hallym Univ, Coll Med, Coll Med, Chunchon 24252, Gangwon, South Korea
[4] Hallym Univ, Hangang Sacred Heart Hosp, Hangang Sacred Heart Hosp, Seoul 150719, South Korea
[5] Hallym Univ, Dept Lab Med, Dongtan Sacred Heart Hosp, Hwaseong, South Korea
[6] Green Cross Labs GC Labs, Dept Lab Med, Yongin 16924, Gyeonggi, South Korea
[7] Soonchunhyang Univ, Dept Ophthalmol, Seoul 04401, South Korea
[8] Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, Seoul 03080, South Korea
关键词
selenium; cognition; APOE4; episodic memory; Alzheimer's disease; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; SELENOPROTEIN P; APOE EPSILON-4; DEMENTIA; CERAD; BRAIN; ANTIOXIDANT;
D O I
10.3390/nu17030595
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Selenium (Se), a vital trace element, plays a neuroprotective role by mitigating oxidative stress through selenoproteins and regulating metal balance. The apolipoprotein E epsilon 4 allele (APOE4), a significant genetic risk factor for Alzheimer's disease (AD), has been linked to reduced Se levels and weakened antioxidant capacity. This research explores the association between serum Se concentrations and cognitive performance, with an emphasis on how APOE4 status influences this relationship. Methods: This study included 196 older adults from community and memory clinic settings, who underwent assessments for episodic memory, global cognition, and non-memory functions using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery, with serum selenium levels analyzed via inductively coupled plasma-mass spectrometry (ICP-MS) and APOE genotyping conducted to determine allele status. Results: Higher serum Se levels were associated with better episodic memory score (EMS) (B = 0.065, 95% CI = 0.020-0.110, p = 0.005) and CERAD total score (TS) (B = 0.119, 95% CI = 0.046-0.193, p = 0.002). However, the interaction between Se and APOE4 status significantly affected EMS (B = -0.074, 95% CI = -0.109 to -0.039, p < 0.001), with significant benefits observed in APOE4-negative participants. Conclusions: This study highlights the genotype-specific impact of Se on cognitive health, emphasizing the need for personalized nutritional interventions targeting Se levels, particularly for APOE4-negative individuals. Future research should further elucidate the mechanisms of Se's effects and assess its therapeutic potential in aging populations.
引用
收藏
页数:13
相关论文
共 60 条
[1]   Role of orexin in pathogenesis of neurodegenerative parkinsonisms [J].
Alster, Piotr ;
Madetko-Alster, Natalia ;
Otto-Slusarczyk, Dagmara ;
Migda, Anna ;
Migda, Bartosz ;
Struga, Marta ;
Friedman, Andrzej .
NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2023, 57 (04) :335-343
[2]   Insights into early pathogenesis of sporadic Alzheimer's disease: role of oxidative stress and loss of synaptic proteins [J].
Ansari, Mubeen A. ;
Rao, Muddanna Sakkattu ;
Al-Jarallah, Aishah .
FRONTIERS IN NEUROSCIENCE, 2024, 17
[3]   Selenium, Selenoproteins, and Immunity [J].
Avery, Joseph C. ;
Hoffmann, Peter R. .
NUTRIENTS, 2018, 10 (09)
[4]   Stability of the preclinical episodic memory deficit in Alzheimer's disease [J].
Bäckman, L ;
Small, BJ ;
Fratiglioni, L .
BRAIN, 2001, 124 :96-102
[5]   Cognitive impairment in preclinical Alzheimer's disease:: A meta-analysis [J].
Bäckman, L ;
Jones, S ;
Berger, AK ;
Laukka, EJ ;
Small, BJ .
NEUROPSYCHOLOGY, 2005, 19 (04) :520-531
[6]   STAGING OF ALZHEIMERS-DISEASE-RELATED NEUROFIBRILLARY CHANGES [J].
BRAAK, H ;
BRAAK, E .
NEUROBIOLOGY OF AGING, 1995, 16 (03) :271-278
[7]   Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration [J].
Burk, Raymond F. ;
Hill, Kristina E. ;
Motley, Amy K. ;
Winfrey, Virginia P. ;
Kurokawa, Suguru ;
Mitchell, Stuart L. ;
Zhang, Wanqi .
FASEB JOURNAL, 2014, 28 (08) :3579-3588
[8]   Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease [J].
Cardoso, Barbara R. ;
Roberts, Blaine R. ;
Malpas, Charles B. ;
Vivash, Lucy ;
Genc, Sila ;
Saling, Michael M. ;
Desmond, Patricia ;
Steward, Christopher ;
Hicks, Rodney J. ;
Callahan, Jason ;
Brodtmann, Amy ;
Collins, Steven ;
Macfarlane, Stephen ;
Corcoran, Niall M. ;
Hovens, Christopher M. ;
Velakoulis, Dennis ;
O'Brien, Terence J. ;
Hare, Dominic J. ;
Bush, Ashley I. .
NEUROTHERAPEUTICS, 2019, 16 (01) :192-202
[9]   The APOE ε4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease [J].
Cardoso, Barbara R. ;
Hare, Dominic J. ;
Lind, Monica ;
McLean, Catriona A. ;
Volitakis, Irene ;
Laws, Simon M. ;
Masters, Colin L. ;
Bush, Ashley I. ;
Roberts, Blaine R. .
ACS CHEMICAL NEUROSCIENCE, 2017, 8 (07) :1459-1464
[10]   Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial [J].
Cardoso, Barbara Rita ;
Apolinario, Daniel ;
Bandeira, Veronica da Silva ;
Busse, Alexandre Leopold ;
Magaldi, Regina Miksian ;
Jacob-Filho, Wilson ;
Franciscato Cozzolino, Silvia Maria .
EUROPEAN JOURNAL OF NUTRITION, 2016, 55 (01) :107-116