Application of composite reference intervals in the diagnosis of subclinical hypothyroidism in the elderly: a retrospective study

被引:0
作者
Li, Peijuan [1 ]
Yang, Wenming [1 ]
Tang, Guohua [2 ]
Li, Zhipeng [1 ]
机构
[1] Sichuan Univ, West China Hosp, Gen Practice Med Ctr, Gen Practice Ward,Int Med Ctr Ward, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Hlth Management Ctr, Gen Practice Med Ctr, Chengdu, Peoples R China
来源
PEERJ | 2024年 / 12卷
关键词
Subclinical hypothyroidism; The elderly; Composite reference intervals; Diagnosis; THYROID-STIMULATING HORMONE; REFERENCE RANGE; FREE-THYROXINE; THYROTROPIN; CUTOFF; TSH;
D O I
10.7717/peerj.18417
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background. Thyroid stimulating hormone releasing hormone (TSH) is a key indicator for diagnosing subclinical hypothyroidism (SCH). We evaluated factors affecting TSH levels in elderly SCH, establishing a composite reference interval, and comparing it with traditional one in diagnosis. Methods. We collected data on patients aged >= 60 undergoing physical examinations in Chengdu, screening the influencing factors associated with TSH. Then, a twodimensional composite reference interval was established for TSH and FT4, and the differences between the new and traditional diagnosing methods were compared. Results. The incidence of subclinical thyroid dysfunction was about 14%, with SCH accounting for 97%. Regression analysis found that TSH levels increase as FT4 and uric acid levels decrease. Compared with the two-dimensional composite reference interval, the traditional one has a higher incidence rate of SCH. Conclusion. Compared with the two-dimensional composite reference interval, the traditional one is more likely to overestimate the incidence rate of SCH, leading to excessive diagnosis and treatment.
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页数:17
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