Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024

被引：1

作者：

Sun, Wanying ^{[1
]}

Choy, Ka Tim ^{[1
]}

Cheng, Ka Man ^{[1
]}

Brackman, Christopher ^{[2
]}

Cheng, Samuel M. S. ^{[1
]}

Sit, Thomas H. C. ^{[2
]}

Tse, Anne C. N. ^{[2
]}

Sims, Leslie D. ^{[3
]}

Gu, Haogao ^{[1
]}

Tang, Amy W. Y. ^{[1
]}

Wong, Andrew N. C. ^{[1
]}

Tsang, Andrew T. L. ^{[1
]}

Koo, Joe C. T. ^{[1
]}

Luk, Leo L. H. ^{[1
]}

Yen, Hui-Ling ^{[1
]}

Peris, Malik ^{[1
,4
,5
,6
]}

Poon, Leo L. M. ^{[1
,4
,5
,6
]}

机构：

[1] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China

[2] Govt Hong Kong Special Adm Reg HKSARG, Hong Kong, Peoples R China

[3] Asia Pacific Vet Informat Serv, Melbourne, Vic, Australia

[4] Ctr Immunol & Infect, Hong Kong, Peoples R China

[5] Univ Hong Kong, HKU Pasteur Res Pole, Hong Kong, Peoples R China

[6] Univ Hong Kong, HKJC Global Hlth Inst, Hong Kong, Peoples R China

来源：

EUROSURVEILLANCE | 2025年 / 30卷 / 01期

关键词：

A VIRUS; BEARING; BIRDS;

D O I：

10.2807/1560-7917.ES.2025.30.1.2400839

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR, 2021-2024. Viruses from two spoon- bills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhib- ited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.

引用

页数：6

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