Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024

被引：1
作者：
Sun, Wanying [1 ]
Choy, Ka Tim [1 ]
Cheng, Ka Man [1 ]
Brackman, Christopher [2 ]
Cheng, Samuel M. S. [1 ]
Sit, Thomas H. C. [2 ]
Tse, Anne C. N. [2 ]
Sims, Leslie D. [3 ]
Gu, Haogao [1 ]
Tang, Amy W. Y. [1 ]
Wong, Andrew N. C. [1 ]
Tsang, Andrew T. L. [1 ]
Koo, Joe C. T. [1 ]
Luk, Leo L. H. [1 ]
Yen, Hui-Ling [1 ]
Peris, Malik [1 ,4 ,5 ,6 ]
Poon, Leo L. M. [1 ,4 ,5 ,6 ]
机构：
[1] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Govt Hong Kong Special Adm Reg HKSARG, Hong Kong, Peoples R China
[3] Asia Pacific Vet Informat Serv, Melbourne, Vic, Australia
[4] Ctr Immunol & Infect, Hong Kong, Peoples R China
[5] Univ Hong Kong, HKU Pasteur Res Pole, Hong Kong, Peoples R China
[6] Univ Hong Kong, HKJC Global Hlth Inst, Hong Kong, Peoples R China
来源：
EUROSURVEILLANCE | 2025年 / 30卷 / 01期
关键词：
A VIRUS; BEARING; BIRDS;
D O I：
10.2807/1560-7917.ES.2025.30.1.2400839
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR, 2021-2024. Viruses from two spoon- bills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhib- ited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.
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页数：6
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