The Minimally Invasive 1-Hour Esophageal String Test Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis

被引：2

作者：

Ackerman, Steven J. ^{[1
]}

Kagalwalla, Amir F. ^{[2
]}

Pan, Zhaoxing ^{[3
,4
]}

Wechsler, Joshua ^{[2
]}

Keeley, Kaitlin ^{[2
]}

Gonsalves, Nirmala ^{[5
]}

Hirano, Ikuo ^{[5
]}

Zalewski, Angelika ^{[5
]}

Menard-Katcher, Paul ^{[6
]}

Menard-Katcher, Calies ^{[3
,4
]}

Gupta, Sandeep K. ^{[7
]}

Chauhan, Nikhil ^{[1
]}

Grozdanovic, Milica ^{[1
]}

Atkins, Dan ^{[8
]}

Nguyen, Nathalie ^{[8
]}

Furuta, Glenn T. ^{[8
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Chicago, IL USA

[3] Univ Colorado, Sch Med, Dept Pediat, Gastrointestinal Eosinophil Dis Program, Aurora, CO USA

[4] Univ Colorado, Mucosal Inflammat Program, Sch Med, Aurora, CO USA

[5] Northwestern Univ, Kenneth C Griffin Esophageal Ctr, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL USA

[6] Univ Colorado Hosp, Sch Med, Div Gastroenterol, Denver, CO USA

[7] Univ Alabama Birmingham, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, Birmingham, AL USA

[8] Univ Colorado, Digest Hlth Inst Childrens Hosp Colorado, Dept Pediat, Gastrointestinal Eosinophil Dis Program,Sch Med, Aurora, CO USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2025年 / 120卷 / 01期

关键词：

eosinophilic esophagitis; pediatric; adult; monitoring; mucosal inflammation; biomarkers; string test; ENDOSCOPY;

D O I：

10.14309/ajg.0000000000003192

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:Endoscopy, standard-of-care for monitoring eosinophilic esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.METHODS:Thirty-three samples from 14 patients with EoE (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs were analyzed for EoEScores.RESULTS:Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.DISCUSSION:The EST can be used to longitudinally monitor responses to treatment in EoE.

引用

页码：254 / 258

页数：5

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