Comprehensive analysis of relapsed-refractory mature B-cell non-Hodgkin lymphoma in children and adolescents

被引：0

作者：

Mato, Sara ^{[1
,2
]}

Carita, Lorenzo

Colmenero, Ariadna ^{[1
,2
]}

Andres, Mara ^{[3
]}

Balague, Olga ^{[4
,5
]}

Andion, Maitane ^{[6
]}

Astigarraga, Itziar ^{[7
,8
]}

Celis, Veronica ^{[9
]}

Mendoza, Carmen ^{[10
]}

Guerra-Garcia, Pilar ^{[11
]}

Valero, Lorena ^{[12
]}

Galera, Ana ^{[13
]}

Tallon, Maria ^{[14
]}

Pol, Melina ^{[1
]}

Castrejon-de-Anta, Natalia ^{[2
,4
]}

Frauenfeld, Leonie ^{[1
]}

Garcia, Noelia ^{[1
]}

Campo, Elias ^{[1
,2
,4
,5
]}

Salaverria, Itziar ^{[1
,5
]}

Verdu-Amoros, Jaime ^{[5
,15
]}

机构：

[1] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Rossello 153, Barcelona 08036, Spain

[2] Univ Barcelona, Barcelona, Spain

[3] Hosp Univ & Politecn La Fe Valencia, Valencia, Spain

[4] Hosp Clin Barcelona, Hematopathol Sect, Lab Pathol, Barcelona, Spain

[5] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[6] Hosp Univ Nino Jesus, Paediat Oncol Dept, Madrid, Spain

[7] Cruces Univ Hosp, Biocruces Bizkaia Hlth Res Inst, Dept Pediat, Bizkaia, Bizkaia, Spain

[8] Univ Basque Country, Baracaldo, Spain

[9] Hosp St Joan de Deu, Pediat Canc Ctr Barcelona, Barcelona, Spain

[10] Complejo Asistencial Univ Salamanca, Paediat Hematooncol Dept, Salamanca, Spain

[11] Hosp Univ La Paz, Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Paediat Haematol & Oncol Dept, Translat Res Paediat Oncol, Madrid, Spain

[12] Hosp Universitari Vall dHebron, Paediat Oncol & Hematol Dept, Barcelona, Spain

[13] Hosp Clin Univ Virgen de la Arrixaca, Dept Oncol, Murcia, Spain

[14] Alvaro Cunqueiro Hosp, Haematooncol Unit, Vigo, Spain

[15] Hosp Clin Univ, INCLIVA, Biomed Res Inst, Dept Paediat Haematol & Oncol, Ave Blasco Ibanez 17, Valencia 46010, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2025年 / 206卷 / 05期

关键词：

Burkitt lymphoma; NHL; paediatric lymphoma; refractory; relapse; TP53; BURKITT-LYMPHOMA; PROGNOSTIC-FACTORS; LEUKEMIA; RITUXIMAB;

D O I：

10.1111/bjh.20012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The outcome of B-cell non-Hodgkin lymphoma (B-NHL) in children and adolescents has improved significantly over recent decades due to risk-adapted strategies and the use of immunotherapy. However, refractory or relapsed (R/R) B-NHL remains extremely difficult to cure (<30%). This retrospective study of 45 patients with R/R B-NHL reflects the limited benefit associated with reintroducing rituximab in second-line strategies, the importance of achieving complete remission before stem cell transplantation and the potential role of TP53 as a biomarker in R/R B-NHL. TP53 mutations were identified in 44% of tumours and associated with a worse 3-year overall survival (15% vs. 80%; p = 0.048).

引用

页码：1390 / 1396

页数：7

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