Antibody-Drug Conjugates for the Treatment of Non-Small Cell Lung Cancer with Central Nervous System Metastases

被引：1

作者：

Bian, David J. H. ^{[1
]}

Cohen, Sara F. ^{[2
]}

Lazaratos, Anna-Maria ^{[3
,4
]}

Bouganim, Nathaniel ^{[5
]}

Dankner, Matthew ^{[1
,4
]}

机构：

[1] McGill Univ, Fac Med & Hlth Sci, Dept Internal Med, Montreal, PQ H3A 1G1, Canada

[2] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 1G1, Canada

[3] Univ Montreal, Fac Med, Montreal, PQ H3A 1G1, Canada

[4] McGill Univ, Rosalind & Morris Goodman Canc Inst, Montreal, PQ H3A 1G1, Canada

[5] McGill Univ Hlth Ctr, Dept Oncol, Montreal, PQ H4A 3J1, Canada

来源：

CURRENT ONCOLOGY | 2024年 / 31卷 / 10期

关键词：

brain metastasis; central nervous system metastasis; non-small-cell lung cancer; lung cancer; antibody-drug conjugate; ADC; BRAIN METASTASES; BREAST-CANCER; TRASTUZUMAB EMTANSINE; OPEN-LABEL; C-MET; PHASE-II; SACITUZUMAB GOVITECAN; SINGLE-ARM; ADVANCED NSCLC; HER2; MUTATION;

D O I：

10.3390/curroncol31100471

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antibody-drug conjugates (ADCs) represent an emerging class of targeted anticancer agents that have demonstrated impressive efficacy in numerous cancer types. In non-small cell lung cancer (NSCLC), ADCs have become a component of the treatment armamentarium for a subset of patients with metastatic disease. Emerging data suggest that some ADCs exhibit impressive activity even in central nervous system (CNS) metastases, a disease site that is difficult to treat and associated with poor prognosis. Herein, we describe and summarize the existing evidence surrounding ADCs in NSCLC with a focus on CNS activity.

引用

页码：6314 / 6342

页数：29

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