Editorial: Pancreatic beta-cell dedifferentiation

被引：0

作者：

Tang, Xiaoqing ^{[1
]}

Kuo, Taiyi ^{[2
]}

Wei, Zong ^{[3
]}

机构：

[1] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA

[2] Univ Calif Davis, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA

[3] Mayo Clin, Dept Physiol & Biomed Engn, Coll Med, Scottsdale, AZ 85259 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷

关键词：

type; 2; diabetes; 1; beta-cell; dedifferentiation; Ca 2+signaling; mitochondria;

D O I：

10.3389/fendo.2024.1524001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 12 条

[1] Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D [J].

Avrahami, Dana ;

Wang, Yue J. ;

Schug, Jonathan ;

Feleke, Eseye ;

Gao, Long ;

Liu, Chengyang ;

Naji, Ali ;

Glaser, Benjamin ;

Kaestner, Klaus H. .

MOLECULAR METABOLISM, 2020, 42

[2] β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[3] Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes [J].

Cinti, Francesca ;

Bouchi, Ryotaro ;

Kim-Muller, Ja Young ;

Ohmura, Yoshiaki ;

Sandoval, P. R. ;

Masini, Matilde ;

Marselli, Lorella ;

Suleiman, Mara ;

Ratner, Lloyd E. ;

Marchetti, Piero ;

Accili, Domenico .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (03) :1044-1054

[4] Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program [J].

Gao, Tao ;

McKenna, Brian ;

Li, Changhong ;

Reichert, Maximilian ;

Nguyen, James ;

Singh, Tarjinder ;

Yang, Chenghua ;

Pannikar, Archana ;

Doliba, Nicolai ;

Zhang, Tingting ;

Stoffers, Doris A. ;

Edlund, Helena ;

Matschinsky, Franz ;

Stein, Roland ;

Stanger, Ben Z. .

CELL METABOLISM, 2014, 19 (02) :259-271

[5] Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice [J].

Gottmann, Pascal ;

Speckmann, Thilo ;

Stadion, Mandy ;

Zuljan, Erika ;

Aga, Heja ;

Sterr, Michael ;

Buettner, Maren ;

Santos, Patricia Martinez ;

Jaehnert, Markus ;

Bornstein, Stefan R. ;

Theis, Fabian J. ;

Lickert, Heiko ;

Schuermann, Annette .

DIABETES, 2022, 71 (09) :1962-1978

[6] Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes [J].

Jonas, JC ;

Sharma, A ;

Hasenkamp, W ;

Ilkova, H ;

Patanè, G ;

Laybutt, R ;

Bonner-Weir, S ;

Weir, GC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) :14112-14121

[7] Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice [J].

Kim-Muller, Ja Young ;

Fan, Jason ;

Kim, Young Jung R. ;

Lee, Seung-Ah ;

Ishida, Emi ;

Blaner, William S. ;

Accili, Domenico .

NATURE COMMUNICATIONS, 2016, 7

[8] Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion [J].

Kuo, Taiyi ;

Kraakman, Michael J. ;

Damle, Manashree ;

Gill, Richard ;

Lazar, Mitchell A. ;

Accili, Domenico .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (40) :20033-20042

[9] Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β cell dysfunction [J].

Kuo, Taiyi ;

Damle, Manashree ;

Gonzalez, Bryan J. ;

Egli, Dieter ;

Lazar, Mitchell A. ;

Accili, Domenico .

JCI INSIGHT, 2019, 4 (13)

[10] MafA is critical for maintenance of the mature beta cell phenotype in mice [J].

Nishimura, Wataru ;

Takahashi, Satoru ;

Yasuda, Kazuki .

DIABETOLOGIA, 2015, 58 (03) :566-574

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