Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment

被引：0
作者：
Sang, Guangze [1 ]
Wang, Bingkai [1 ]
Xie, Yujie [2 ]
Chen, Yu [3 ]
Yang, Feng [1 ]
机构：
[1] Naval Med Univ, Sch Pharm, Dept Inorgan Chem, Shanghai 200433, Peoples R China
[2] Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
[3] Shanghai Univ, Sch Life Sci, Materd Lab, Shanghai 200444, Peoples R China
来源：
THERANOSTICS | 2025年 / 15卷 / 08期
基金：
中国国家自然科学基金;
关键词：
engineered probiotic-based materials; living materials; inflammatory bowel disease; probiotics; LACTOBACILLUS-RHAMNOSUS GG; ULCERATIVE-COLITIS; LACTOCOCCUS-LACTIS; GUT MICROBIOTA; TARGETED DELIVERY; SOLUBLE-PROTEIN; MURINE COLITIS; CROHNS-DISEASE; BARRIER; ACID;
D O I：
10.7150/thno.103983
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inflammatory bowel disease (IBD) is a chronic condition affecting the intestines, marked by immune-mediated inflammation. This disease is known for its recurrent nature and the challenges it presents in treatment. Recently, probiotic have gained attention as a promising alternative to traditional small molecular drugs and monoclonal antibody chemotherapies for IBD. Probiotic, recognized as a "living" therapeutic agent, offers targeted treatment with minimal side effects and the flexibility for biological modifications, making them highly effective for IBD management. This comprehensive review presents the latest advancements in engineering probiotic-based materials, ranging from basic treatment mechanisms to the modification techniques used in IBD management. It delves deep into how probiotic produces therapeutic effects in the intestinal environment and discusses various strategies to enhance probiotic's efficacy, including genetic modifications and formulation improvements. Additionally, the review addresses the challenges, practical application conditions, and future research directions of probiotic-based therapies in IBD treatment, providing insights into their feasibility and potential clinical implications.
引用
收藏
页码：3289 / 3315
页数：27
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