Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade

被引：1

作者：

Li, Lei ^{[1
]}

Ge, Zhengping ^{[1
,2
]}

Liu, Shihao ^{[1
]}

Zheng, Kun ^{[1
,3
]}

Li, Yaqi ^{[1
]}

Chen, Kaiqi ^{[4
]}

Fu, Yesheng ^{[1
]}

Lei, Xiaoguang ^{[4
,5
]}

Cui, Zeling ^{[1
]}

Wang, Yifan ^{[1
]}

Huang, Jin ^{[1
,6
]}

Liu, Yanyan ^{[1
,7
]}

Duan, Mingwang ^{[1
]}

Sun, Zimei ^{[1
]}

Chen, Jun ^{[1
]}

Li, Liangwei ^{[8
,9
]}

Shen, Pan ^{[1
]}

Wang, Guibin ^{[1
]}

Chen, Junmiao ^{[10
]}

Li, Ruochong ^{[11
]}

Li, Chaoran ^{[1
]}

Yang, Zhixiang ^{[12
]}

Ning, Yifan ^{[12
]}

Luo, Arong ^{[13
]}

Chen, Baoyu ^{[14
]}

Seim, Inge ^{[15
]}

Liu, Xin ^{[8
]}

Wang, Fei ^{[1
]}

Yao, Yishan ^{[16
]}

Guo, Fusheng ^{[4
]}

Yang, Maojun ^{[11
]}

Liu, Cui Hua ^{[17
]}

Fan, Guangyi ^{[8
]}

Wang, Lizhi ^{[14
]}

Yang, Dong ^{[1
]}

Zhang, Lingqiang ^{[1
]}

机构：

[1] Beijing Inst Life, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Med Prote, Beijing 102206, Peoples R China

[2] Qingdao Univ, Sch Basic Med, Dept Immunol, Qingdao 266071, Peoples R China

[3] Gen Hosp Southern Theater Command, Dept Orthoped, Guangzhou 510010, Peoples R China

[4] Peking Univ, Coll Chem & Mol Engn, Peking Tsinghua Ctr Life Sci, Beijing Natl Lab Mol Sci,Minist Educ,Key Lab Bioor, Beijing 100871, Peoples R China

[5] Inst Canc Res, Shenzhen Bay Lab, Shenzhen 518107, Peoples R China

[6] Univ South China, Hengyang Med Sch, Dept Biol, Hengyang 421001, Peoples R China

[7] Anhui Med Univ, Sch Basic Med, Dept Pathophysiol, Hefei 230032, Peoples R China

[8] BGI Res, Shenzhen 518083, Peoples R China

[9] BGI Res, Qingdao 266555, Peoples R China

[10] SCIEX China, Beijing 100015, Peoples R China

[11] Tsinghua Univ, Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Sch Life Sci,Minist Educ,Key Lab Prot Sci, Beijing 100084, Peoples R China

[12] Hebei Univ, Coll Life Sci, Baoding 071000, Peoples R China

[13] Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China

[14] Shaanxi Xueqian Normal Univ, Coll Life Sci & Food Engn, Xian 710100, Peoples R China

[15] Chinese Acad Sci, Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya 572006, Peoples R China

[16] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

[17] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

来源：

SCIENCE | 2024年 / 386卷 / 6720期

基金：

中国国家自然科学基金;

关键词：

HORIZONTAL GENE-TRANSFER; SPECIES DELIMITATION; BETALAINS; BIOSYNTHESIS; TRANSLOCATION; PROTEINS; GENOMICS; SURVIVAL; MICE; TREE;

D O I：

10.1126/science.adl0799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of Hypsibius henanensis sp. nov., we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (DODA1), responds to radiation and confers radiotolerance by synthesizing betalains-a type of plant pigment with free radical-scavenging properties. A tardigrade-specific radiation-induced disordered protein, TRID1, facilitates DNA damage repair through a mechanism involving phase separation. Two mitochondrial respiratory chain complex assembly proteins, BCS1 and NDUFB8, accumulate to accelerate nicotinamide adenine dinucleotide (NAD+) regeneration for poly(adenosine diphosphate-ribosyl)ation (PARylation) and subsequent poly(adenosine diphosphate-ribose) polymerase 1 (PARP1)-mediated DNA damage repair. These three observations expand our understanding of mechanisms of tardigrade radiotolerance.

引用

页数：13

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