Iridium-Catalyzed Leuckart-Type Reductive Amination of Carbonyls

被引：0

作者：

Luo, Renshi ^{[1
,2
]}

Liu, Liang ^{[1
,2
]}

Tong, Jinghui ^{[2
]}

Ouyang, Lu ^{[2
]}

Liao, Jianhua ^{[2
]}

机构：

[1] Shaoguan Univ, Coll Chem & Environm Engn, Shaoguan 512005, Peoples R China

[2] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 03期

基金：

中国国家自然科学基金;

关键词：

iridium; Leuckart-type; reductive amination; carbonyls; formamides; SELECTIVE N-FORMYLATION; AMINES; DIOXIDE; TRANSAMIDATION; CARBOXAMIDES; FORMAMIDES; HYDROGEN; METHANOL; ALCOHOLS; GOLD;

D O I：

10.1055/a-2412-9481

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Formamides are fundamental motifs that are prevalent in drugs, pesticides, dyes, and fragrances. Herein, we described an iridium-catalyzed Leuckart-type reductive amination of carbonyls, delivering formamides in moderate to excellent yields. In this process, ammonium formate was used as the N-formylating reagent to produce the formamide products. This protocol provides a new procedure for formamide synthesis.

引用

页码：629 / 636

页数：8

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