Collaborative Prediction of Drug-target Interaction using Sequence-based CNN and Transformer

Drug-target interaction (DTI) prediction is a critical step in drug discovery. Deep learning has shown great potential in DTI prediction. In recent years, many sequence-based DTI prediction methods have been proposed. However, the current methods do not fully represent drugs and proteins and ignore the local and global features of these molecules. In response to these challenges, we propose a sequence-based CNN and Transformer collaborative prediction method (SCTDTI) for drug-target interaction. We train and evaluate our proposed approach on two public drug-target datasets, and experimental results show that SCTDTI improves DTI prediction performance compared to state-of-the-art baselines.