Emerging role of aquaporin in neurodegenerative diseases: A novel target for drug development

被引：1

作者：

Zhou, Mengzhen ^{[1
]}

Liu, Ruen ^{[1
]}

机构：

[1] Peking Univ, Peoples Hosp, Neurol, Beijing 100044, Peoples R China

来源：

LEARNING AND MOTIVATION | 2025年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Neurodegeneration; Alzheimer's; Glymphatic clearance; Amyloid clearance; ARCSWE MOUSE MODEL; ALZHEIMERS-DISEASE; AQP4; IMPAIRMENT; LOCALIZATION; ASSOCIATION; COGNITION; EXERCISE; FLUID;

D O I：

10.1016/j.lmot.2024.102083

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Background: The early manifestations of Alzheimer's patients are a decline in learning and motivation, forgetfulness, especially what has just happened, and they become passive, unmotivated, and lose interest in hobbies. It is believed that the main pathological changes in Alzheimer's disease are abnormal deposition of (3-amyloid (A(3) protein and phosphorylation of tau in the brain, and various in vitro and in vivo experiments have shown that aquaporin-4 (AQP4) may be responsible for A(3 metabolism and clearance in Alzheimer's disease. Objective: To provide a new direction for the diagnosis and treatment of Alzheimer's disease by characterizing the structure and function of AQP4 and the function and possible mechanism of AQP4 in the clearance of A(3 in Alzheimer's disease. Conclusion: Strengthening of the regulatory effect of AQP4 on lymphatic function in the brain has an important effect on the development, progression and outcome of Alzheimer's disease. AQP4 agonists or agents that induce AQP4 opening are expected to become novel treatments for Alzheimer's disease.

引用

页数：8

共 72 条

[1] High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases [J].

Aldewachi, Hasan ;

Al-Zidan, Radhwan N. ;

Conner, Matthew T. ;

Salman, Mootaz M. .

BIOENGINEERING-BASEL, 2021, 8 (02) :1-20

[2] Astrocytes in functional recovery following central nervous system injuries [J].

Alhadidi, Qasim M. ;

Bahader, Ghaith A. ;

Arvola, Oiva ;

Kitchen, Philip ;

Shah, Zahoor A. ;

Salman, Mootaz M. .

JOURNAL OF PHYSIOLOGY-LONDON, 2024, 602 (13) :3069-3096

[3] Spatial Dynamics of Vascular and Biochemical Injury in Rat Hippocampus Following Striatal Injury and A Toxicity [J].

Amtul, Zareen ;

Frias, Carmen ;

Randhawa, Jasmine ;

Hill, David J. ;

Arany, Edith J. .

MOLECULAR NEUROBIOLOGY, 2019, 56 (04) :2714-2727

[4] Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease? [J].

Arighi, Andrea ;

Di Cristofori, Andrea ;

Fenoglio, Chiara ;

Borsa, Stefano ;

D'Anca, Marianna ;

Fumagalli, Giorgio Giulio ;

Locatelli, Marco ;

Carrabba, Giorgio ;

Pietroboni, Anna Margherita ;

Ghezzi, Laura ;

Carandini, Tiziana ;

Colombi, Annalisa ;

Scarioni, Marta ;

De Riz, Milena Alessandra ;

Serpente, Maria ;

Rampini, Paolo Maria ;

Scarpini, Elio ;

Galimberti, Daniela .

JOURNAL OF ALZHEIMERS DISEASE, 2019, 69 (03) :663-669

[5] Reactive Astrocytes as Drug Target in Alzheimer's Disease [J].

Assefa, Brhane Teklebrhan ;

Gebre, Abadi Kahsu ;

Altaye, Birhanetensay Masresha .

BIOMED RESEARCH INTERNATIONAL, 2018, 2018

[6] Astrocyte Biomarkers in Alzheimer Disease A Systematic Review and Meta-analysis [J].

Bellaver, Bruna ;

Ferrari-Souza, Joao Pedro ;

da Ros, Lucas Uglione ;

Carter, Stephen F. ;

Rodriguez-Vieitez, Elena ;

Nordberg, Agneta ;

Pellerin, Luc ;

Rosa-Neto, Pedro ;

Leffa, Douglas Teixeira ;

Zimmer, Eduardo R. .

NEUROLOGY, 2021, 96 (24) :E2944-E2955

[7] Brain water channel proteins in health and disease [J].

Benga, Oana ;

Huber, Vincent J. .

MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (5-6) :562-578

[8] Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer's Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant [J].

Beuckmann, Carsten T. ;

Suzuki, Hiroyuki ;

Musiek, Erik S. ;

Ueno, Takashi ;

Sato, Toshitaka ;

Bando, Masahiro ;

Osada, Yoshihide ;

Moline, Margaret .

JOURNAL OF ALZHEIMERS DISEASE, 2021, 81 (03) :1151-1167

[9] Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer's Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer's Disease [J].

Boespflug, Erin L. ;

Simon, Matthew J. ;

Leonard, Emmalyn ;

Grafe, Marjorie ;

Woltjer, Randall ;

Silbert, Lisa C. ;

Kaye, Jeffrey A. ;

Iliff, Jeffrey J. .

JOURNAL OF ALZHEIMERS DISEASE, 2018, 66 (04) :1587-1597

[10] Astrocyte Function Is Affected by Aging and Not Alzheimer's Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice [J].

Bronzuoli, Maria Rosanna ;

Facchinetti, Roberta ;

Valenza, Marta ;

Cassano, Tommaso ;

Steardo, Luca ;

Scuderi, Caterina .

FRONTIERS IN PHARMACOLOGY, 2019, 10

← 1 2 3 4 5 6 7 8 →