Head and neck Cytopathology: Options for high-risk HPV testing in head and neck FNA specimens, a concise review

被引：1

作者：

Hou, Tieying ^{[1
]}

Mesa, Hector ^{[1
]}

Chen, Shaoxiong ^{[1
]}

Bikhet, Mohamed Hamdi Fouad ^{[1
]}

Saeed, Omer ^{[1
]}

Segura, Sheila ^{[1
]}

Cramer, Harvey ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN USA

来源：

HUMAN PATHOLOGY REPORTS | 2024年 / 35卷

关键词：

SQUAMOUS-CELL CARCINOMA; FINE-NEEDLE-ASPIRATION; IN-SITU HYBRIDIZATION; HUMAN-PAPILLOMAVIRUS STATUS; LYMPH-NODE METASTASIS; P16; EXPRESSION; BROAD-SPECTRUM; DNA DETECTION; OROPHARYNGEAL; CANCER;

D O I：

10.1016/j.hpr.2024.300731

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

High-risk human papillomavirus (HR-HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a unique form of head and neck cancer with distinct biology and better prognosis than conventional SCC. Many patients with HR-HPV positive OPSCC initially present with metastases to lateral neck lymph nodes in levels II or III. Fine-needle aspiration (FNA) is routinely used to establish a diagnosis and evaluate HPV status at these sites. However, there is no consensus regarding the best testing methods for establishing HPV status in cytology specimens. The most common methods include p16 immunohistochemistry, HR-HPV in situ hybridization and molecular tests. This review summarizes the advantages and limitation of each method.

引用

页数：8

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