Gut microbiota in melanoma: Effects and pathogeneses

被引：0

作者：

Liu, Wenwen ^{[1
,2
]}

Yang, Xin ^{[1
,2
]}

Zhou, Yuwei ^{[1
,2
]}

Huang, Ziru ^{[1
,2
]}

Huang, Jian ^{[1
,2
,3
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Canc Hosp, Sichuan Clin Res Ctr Canc, Dept Clin Lab, Chengdu 611731, Sichuan, Peoples R China

[2] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 611731, Sichuan, Peoples R China

[3] Chengdu Neusoft Univ, Sch Healthcare Technol, Chengdu, Sichuan, Peoples R China

来源：

MICROBIOLOGICAL RESEARCH | 2025年 / 296卷

关键词：

Gut microbiota; Melanoma; Immunity; Effects; Pathogeneses; SEX-DIFFERENCES; DIETARY FIBER; IMMUNOTHERAPY; SURVIVAL; AGE; PROGNOSIS; IMMUNITY; THERAPY; HEALTH; RISK;

D O I：

10.1016/j.micres.2025.128144

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gut microbiota exhibits intricate connections with the body's immune system and holds significant implications for various diseases and cancers. Currently, accumulating evidence suggests a correlation between the composition of the gut microbiota and the development, treatment, and prognosis of melanoma. However, the underlying pathogenesis remains incompletely elucidated. In this comprehensive review, we present an in-depth review of the role played by gut microbiota in melanoma tumorigenesis, growth, metastasis, treatment response, and prognosis. Furthermore, we discuss the potential utility of gut microbiota as a promising prognostic marker. Lastly, we summarize three routes through which gut microbiota influences melanoma: immunity, aging, and the endocrine system. By modulating innate and adaptive immunity in patients with melanoma across different age groups and genders, the gut microbiota plays a crucial role in anti-tumor immune regulation from tumorigenesis to prognosis management, thereby impacting tumor growth and metastasis. This review also addresses current study limitations while highlighting future research prospects.

引用

页数：12

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