Synthesis of 2,3,5,6-Tetrasubstituted Thieno[3,2-b]furans through Formal [3+2] Cycloaddition Utilizing [1,2]-Phospha-Brook Rearrangement/Brønsted Base-Mediated Cyclization Sequence

被引：0
|
作者：
Kondoh, Azusa [1 ]
Aita, Kohei [2 ]
Terada, Masahiro [2 ]
机构：
[1] Tohoku Univ, Res & Analyt Ctr Giant Mol, Grad Sch Sci, Aoba ku, Sendai 9808578, Japan
[2] Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba ku, Sendai 9808578, Japan
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 22期
关键词：
Thieno[3,2-b]furan; 1,2]-Phospha-Brook rearrangement; Formal [3+2] cycloaddition; Br & oslash; nsted base; Cyclization; ANNULATION;
D O I：
10.1002/adsc.202400767
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We have developed a method for the synthesis of thieno[3,2-b]furans on the basis of a strategy consisting of a formal [3+2] cycloaddition utilizing the [1,2]-phospha-Brook rearrangement and a subsequent Br & oslash;nsted base-mediated cyclization. The method streamlines access to a wide range of well-organized 2,3,5,6-tetrasubstituted thieno[3,2-b]furans that are otherwise difficult to synthesize and is also applicable to the syntheses of 2,3,5,6-tetrasubstituted seleno[3,2-b]furans.
引用
收藏
页码：4723 / 4728
页数：6
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