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- [41] Bliss T.V., Collingridge G.L., Kaang B.K., Zhuo M., Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain, Nat Rev Neurosci, 17, 8, pp. 485-496, (2016)
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study
被引：0
作者：
Jia, Zhihua
[1
,2
]
Wan, Dongjun
[3
]
Yin, Ziming
[4
]
Fan, Zhiliang
[5
]
Xu, Peng
[6
]
Yuan, Xueqian
[7
]
Chen, Min
[8
]
Wang, Dan
[9
]
Wang, Hebo
[10
]
Wang, Shengshu
[11
]
Zhang, Shuhua
[12
]
Liu, Ruozhuo
[2
,12
]
Wang, Xiaolin
[2
,12
]
Wang, Rongfei
[2
,12
]
Su, Hui
[2
,12
]
Han, Xun
[2
,12
]
Yu, Zhe
[2
,12
]
Li, Yingji
[2
,12
]
Yu, Shengyuan
[2
,12
]
Dong, Zhao
[2
,12
]
机构：
[1] Chinese PLA, Dept Gastroenterol, Med Ctr 2, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Int Headache Ctr, Fuxing Rd 28, Beijing 100853, Peoples R China
[3] Chinese Peoples Liberat Army, 940 Hosp Joint Logist Support Force, Dept Neurol, Lanzhou, Gansu, Peoples R China
[4] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai, Peoples R China
[5] Xingtai Peoples Hosp, Dept Neurol, Xingtai, Hebei, Peoples R China
[6] Jining Med Univ, Affiliated Hosp, Dept Neurol, Jining, Shandong, Peoples R China
[7] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Peoples R China
[8] First Affiliated Hosp Zhengzhou Univ, Dept Neurol, Zhengzhou, Henan, Peoples R China
[9] Gen Hosp Northern Theatre Command, Dept Neurol, Shenyang, Peoples R China
[10] Hebei Gen Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China
[11] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Aging & Geriatr, Med Ctr 2, Inst Geriatr,Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China
[12] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurol, Fuxing Rd 28, Beijing 100853, Peoples R China
来源：
关键词：
Primary headache;
depression;
anxiety;
comorbidity;
chronic headache;
CLUSTER HEADACHE;
MIGRAINE;
PREVALENCE;
EPIDEMIOLOGY;
PAIN;
D O I：
10.1177/17448069251314271
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: Primary headache and psychiatric diseases are bidirectional correlated. The real-world data of depression and anxiety in Chinese patients hospitalized for primary headache, considering all subtypes, remain unclear.Methods: This study enrolled patients attending eight Chinese headache centers from October 2022 to September 2023. A WeChat mini-program was designed to collect data. Headache was diagnosed and confirmed by two headache specialists. The Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 were used to assess depression and anxiety.Results: Overall, 1963 patients with primary headache were analyzed; the prevalence of depression and anxiety was 20.1% (396/1963) and 14.8% (290/1963), respectively. Of the 1963 patients, 217 (11.1%) had history of anxiety or depression and 184 (9.4%) had undergone assessments. Patients with both primary headache and depression were more likely to be women (77.8% vs 71.9%), experience more severe headache (numerical rating scale; 6.2 +/- 1.9 vs 5.7 +/- 1.9) and greater impacts on quality of life (Headache Impact Test-6; 65.3 +/- 8.5 vs 58.1 +/- 11.5). Those with both primary headache and anxiety exhibited similar results and were less educated. Depression and anxiety were more prevalent in chronic migraineurs (CM) than in episodic migraineurs (36.8% vs 16.9% and 28.9% vs 12.3%, respectively) and in those with chronic (CTTH) than in those with episodic tension-type headache (30.6% vs 15.1% and 20.1% vs 12.8%, respectively).Conclusion: Depression and anxiety are inadequately diagnosed and strongly associated with sex, severe headache, chronification and disability in patients with primary headache in China. To improve the health of patients with primary headaches, early screening for depression and anxiety is important.
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