A Rare Case of Diffuse Large B-Cell Lymphoma With MYC and BCL2 Gene Translocations Diagnosed Due to Temporomandibular Joint Symptoms

被引：0
作者：
Hayashi, Hirosaka [1 ]
Hayasaka, Junichi [1 ,2 ,3 ]
Sakuyama, Aoi [1 ]
Watanabe, Hideki [1 ,4 ]
Jinbu, Yoshinori [1 ]
Noguchi, Tadahide [1 ]
机构：
[1] Jichi Med Univ, Dept Dent Oral & Maxillofacial Surg, Shimotsuke, Tochigi, Japan
[2] Haga Red Cross Hosp, Div Dent Oral & Maxillofacial Surg 2, Mooka, Tochigi, Japan
[3] Jichi Med Univ, Haga Reg Clin Educ Ctr, Mooka, Tochigi, Japan
[4] Jichi Med Univ, Saitama Med Ctr, Dept Dent Oral & Maxillofacial Surg, Saitama, Tochigi, Japan
来源：
ORAL SCIENCE INTERNATIONAL | 2025年 / 22卷 / 01期
关键词：
cervical lymphadenopathy; diffuse large B-cell lymphoma; double-hit lymphoma; lymph node biopsy; SURGICAL EXCISIONAL BIOPSY; NODE BIOPSY;
D O I：
10.1002/osi2.1288
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
BackgroundDouble-hit lymphoma shows a poor prognosis, necessitating early diagnosis to improve prognosis.Case PresentationA 68-year-old Japanese woman presented with pain and a click in the right temporomandibular joint. The right side of her neck was acutely swollen. A biopsy of a mass lesion and lymph node suggested diffuse large B-cell lymphoma; chromosomal analyses revealed MYC and BCL2 rearrangements. Complete response was achieved with chemotherapy. Peripheral blood stem cell transplantation was performed, but the patient relapsed. She died due to respiratory failure.ConclusionDouble-hit lymphoma is often accompanied by cervical lymphadenopathy. Lymph node biopsy is useful for early diagnosis.
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