Automated ultrasonography of hepatocellular carcinoma using discrete wavelet transform based deep-learning neural network

This study introduces HCC-Net, a novel wavelet-based approach for the accurate diagnosis of hepatocellular carcinoma (HCC) from abdominal ultrasound (US) images using artificial neural networks. The HCC-Net integrates the discrete wavelet transform (DWT) to decompose US images into four sub-band images, a lesion detector for hierarchical lesion localization, and a pattern-augmented classifier for generating pattern-enhanced lesion images and subsequent classification. The lesion detection uses a hierarchical coarse-to-fine approach to minimize missed lesions. CoarseNet performs initial lesion localization, while FineNet identifies any lesions that were missed. In the classification phase, the wavelet components of detected lesions are synthesized to create pattern-augmented images that enhance feature distinction, resulting in highly accurate classifications. These augmented images are classified into 'Normal,' 'Benign,' or 'Malignant' categories according to their morphologic features on sonography. The experimental results demonstrate the significant effectiveness of the proposed coarse-to-fine detection framework and pattern-augmented classifier in lesion detection and classification. We achieved an accuracy of 96.2 %, a sensitivity of 97.6 %, and a specificity of 98.1 % on the Samsung Medical Center dataset, indicating HCC-Net's potential as a reliable tool for liver cancer screening.