Examining the use of a continuous marker of metabolic syndrome severity for detecting resting autonomic dysfunction in a multiracial sample of young adults

被引：0

作者：

Newsome, Ta'Quoris A. ^{[1
]}

Graybeal, Austin J. ^{[2
]}

Aultman, Ryan S. ^{[2
]}

Vallecillo-Bustos, Anabelle ^{[2
]}

Brandner, Caleb F. ^{[3
]}

Swafford, Sydney H. ^{[2
]}

Compton, Abby T. ^{[2
]}

Parnell, Sarah ^{[2
]}

Schimpf, Rhett C. ^{[2
]}

Thorsen, Tanner ^{[2
]}

Renna, Megan E. ^{[4
]}

Stavres, Jon ^{[2
]}

机构：

[1] Univ Mississippi Med Ctr, Sch Med, Jackson, MS USA

[2] Univ Southern Mississippi, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA

[3] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA USA

[4] Univ Southern Mississippi, Sch Psychol, Hattiesburg, MS USA

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2025年 / 12卷

关键词：

metabolic syndrome; baroreflex sensitivity; blood pressure; heart rate variability; risk assessment; SYMPATHETIC NEURAL ACTIVATION; HYPERGLYCEMIA; INSULIN; VASODILATION; SENSITIVITY; FAT;

D O I：

10.3389/fcvm.2025.1508805

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims To determine if a continuous marker of metabolic syndrome (MetS) severity (MetSindex) could identify early-onset autonomic dysfunction in young adults at an elevated risk (ER) of MetS.Methods Blood biomarkers and anthropometrics were collected from 178 individuals. Cardiovagal baroreflex sensitivity (cBRS) and heart rate variability (HRV) were evaluated during 10-min of rest. Linear regressions examined the associations between the MetSindex and cBRS, as well as select indices of HRV. These variables were also compared between individuals meeting the criteria for MetS (MetS group), individuals not meeting the criteria for MetS but having a positive MetSindex (ER), and healthy controls (Con) matched for sex, race, and ethnicity (n = 20 per group).Results All indices of cBRS (all p <= 0.007) and the standard deviation of normal-to-normal r-r intervals (SDNN; p = 0.001) were attenuated in the MetS group compared to the Con group. However, no differences were observed between the Con and ER groups (p >= 0.395). The MetSindex did demonstrate a significant, albeit small (R2 <= 0.038, beta <= -0.168, p <= 0.028) association with all indices of cBRS and SDNN.Conclusions The MetSindex is associated with indices of cBRS and HRV, but is not currently able to detect early-onset autonomic dysfunction in young adults with an elevated risk of MetS.

引用

页数：9