Rh(III)-Catalyzed Aminoalkylation of Alkenes with Diazo Compounds toward Functionalized Isoindolinones

被引：0

作者：

Liu, Yuying ^{[1
,2
,3
,4
]}

Fu, Zhanwei ^{[1
,2
,3
,4
]}

Yang, Chao ^{[4
]}

Luo, Mupeng ^{[4
]}

Ban, Shurong ^{[1
,2
,3
]}

Wang, Shougu ^{[4
]}

机构：

[1] Shanxi Med Univ, Sch Pharm, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Med Basic Res Innovat Ctr Chron Kidney Dis, Minist Educ, Taiyuan 030001, Peoples R China

[3] Shanxi Med Univ, Shanxi Prov Key Lab Drug Synth & Novel Pharmaceut, Taiyuan 030001, Peoples R China

[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 11期

关键词：

aminoalkylation reaction; annulation reaction; isoindolinone; Rh(III)-catalysis; diazo compounds; NEUTRAL 4+1 ANNULATION; AZA-HECK CYCLIZATIONS; H INSERTION REACTION; ASYMMETRIC-SYNTHESIS; CARBENE INSERTION; 3-SUBSTITUTED ISOINDOLINONES; ENANTIOSELECTIVE SYNTHESIS; CATALYZED REACTIONS; OLEFINIC AMIDES; RUTHENIUM;

D O I：

10.6023/cjoc202405016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A [Cp*RhCl2]2-catalyzed intramolecular annulation reaction via aminoalkylation of alkenes with diazo compounds has been developed to construct highly-functionalized isoindolinones. This approach exhibits step economy, mild reaction conditions, and good functional group tolerance, facilitating access to a wide range of highly-valuable functionalized isoindolinones with high level of yields (up to 99% yield).

引用

页码：3505 / 3517

页数：13

共 39 条

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