Rh(III)-Catalyzed Aminoalkylation of Alkenes with Diazo Compounds toward Functionalized Isoindolinones

被引：0
|
作者：
Liu, Yuying [1 ,2 ,3 ,4 ]
Fu, Zhanwei [1 ,2 ,3 ,4 ]
Yang, Chao [4 ]
Luo, Mupeng [4 ]
Ban, Shurong [1 ,2 ,3 ]
Wang, Shougu [4 ]
机构：
[1] Shanxi Med Univ, Sch Pharm, Taiyuan 030001, Peoples R China
[2] Shanxi Med Univ, Med Basic Res Innovat Ctr Chron Kidney Dis, Minist Educ, Taiyuan 030001, Peoples R China
[3] Shanxi Med Univ, Shanxi Prov Key Lab Drug Synth & Novel Pharmaceut, Taiyuan 030001, Peoples R China
[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 11期
关键词：
aminoalkylation reaction; annulation reaction; isoindolinone; Rh(III)-catalysis; diazo compounds; NEUTRAL 4+1 ANNULATION; AZA-HECK CYCLIZATIONS; H INSERTION REACTION; ASYMMETRIC-SYNTHESIS; CARBENE INSERTION; 3-SUBSTITUTED ISOINDOLINONES; ENANTIOSELECTIVE SYNTHESIS; CATALYZED REACTIONS; OLEFINIC AMIDES; RUTHENIUM;
D O I：
10.6023/cjoc202405016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A [Cp*RhCl2]2-catalyzed intramolecular annulation reaction via aminoalkylation of alkenes with diazo compounds has been developed to construct highly-functionalized isoindolinones. This approach exhibits step economy, mild reaction conditions, and good functional group tolerance, facilitating access to a wide range of highly-valuable functionalized isoindolinones with high level of yields (up to 99% yield).
引用
收藏
页码：3505 / 3517
页数：13
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