Biological effects of combinations of structurally diverse human milk oligosaccharides

被引:1
|
作者
Wichmann, Anita [1 ]
机构
[1] DSM Firmenich, Global Regulatory Affairs HMOs Early Life & Med Nu, Horsholm, Denmark
来源
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词
human milk oligosaccharides; pediatric nutrition; gut microbiota; pathogen inhibition; cognitive development; SIALIC-ACID; ROTAVIRUS INFECTIVITY; NOROVIRUS INHIBITION; GUT; BINDING; SIALYLLACTOSE; CONSUMPTION; METABOLISM; GLYCANS; PIGLET;
D O I
10.3389/fped.2024.1439612
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Human milk oligosaccharides (HMOs) are a diverse group of structures and an abundant bioactive component of breastmilk that contribute to infant health and development. Preclinical studies indicate roles for HMOs in shaping the infant gut microbiota, inhibiting pathogens, modulating the immune system, and influencing cognitive development. In the past decade, several industrially produced HMOs have become available to fortify infant formula. Clinical intervention trials with manufactured HMOs have begun to corroborate some of the physiological effects reported in preclinical studies, especially modulation of the gut microbiota in the direction of breastfed infants. As more HMOs become commercially available and as HMOs have some shared mechanisms of action, there is a need to better understand the unique and differential effects of individual HMOs and the benefits of combining multiple HMOs. This review focuses on the differential effects of different HMO structural classes and individual structures and presents a scientific rationale for why combining multiple structurally diverse HMOs is expected to exert greater biological effects.
引用
收藏
页数:14
相关论文
共 50 条
  • [31] Potential biological functions and future perspectives of sialylated milk oligosaccharides
    Nguyen, Thuy Le Lam
    Nguyen, Dung Van
    Heo, Kyung-Sun
    ARCHIVES OF PHARMACAL RESEARCH, 2024, 47 (04) : 325 - 340
  • [32] Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated Akkermansia Is Strain Dependent
    Luna, Estefani
    Parkar, Shanthi G.
    Kirmiz, Nina
    Hartel, Stephanie
    Hearn, Erik
    Hossine, Marziiah
    Kurdian, Arinnae
    Mendoza, Claudia
    Orr, Katherine
    Padilla, Loren
    Ramirez, Katherine
    Salcedo, Priscilla
    Serrano, Erik
    Choudhury, Biswa
    Paulchakrabarti, Mousumi
    Parker, Craig T.
    Huynh, Steven
    Cooper, Kerry
    Flores, Gilberto E.
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2022, 88 (01)
  • [33] Potential biological functions and future perspectives of sialylated milk oligosaccharides
    Thuy Le Lam Nguyen
    Dung Van Nguyen
    Kyung-Sun Heo
    Archives of Pharmacal Research, 2024, 47 : 325 - 340
  • [34] Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents
    Rousseaux, Anais
    Brosseau, Carole
    Le Gall, Sophie
    Piloquet, Hugues
    Barbarot, Sebastien
    Bodinier, Marie
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [35] Differences in the content of human milk oligosaccharides between foremilk and hind milk
    Pu, Zhiping
    Sun, Zhaona
    Liu, Jun
    Zhang, Jinyue
    Cheng, Mengdi
    Zhang, Lina
    Zhou, Peng
    FOOD BIOENGINEERING, 2023, 2 (02): : 105 - 113
  • [36] Interactions between Bifidobacterium and Bacteroides and human milk oligosaccharides and their associations with infant cognition
    Cho, Seoyoon
    Samuel, Tinu M.
    Li, Tengfei
    Howell, Brittany R.
    Baluyot, Kristine
    Hazlett, Heather C.
    Elison, Jed T.
    Zhu, Hongtu
    Hauser, Jonas
    Sprenger, Norbert
    Lin, Weili
    FRONTIERS IN NUTRITION, 2023, 10
  • [37] Recent trends in human milk oligosaccharides: New synthesis technology, regulatory effects, and mechanisms of non-intestinal functions
    Chen, Qingxue
    Wang, Xiangxin
    Zhang, Peng
    Li, Bailiang
    COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 2025, 24 (02):
  • [38] Human Milk Oligosaccharides and Infant Neurodevelopment: A Narrative Review
    Berger, Paige K.
    Ong, Margaret L.
    Bode, Lars
    Belfort, Mandy B.
    NUTRIENTS, 2023, 15 (03)
  • [39] In Vitro Impact of Human Milk Oligosaccharides on Enterobacteriaceae Growth
    Hoeflinger, Jennifer L.
    Davis, Steven R.
    Chow, JoMay
    Miller, Michael J.
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 63 (12) : 3295 - 3302
  • [40] Characterization and Quantification of Oligosaccharides in Human Milk and Infant Formula
    Nijman, Rose M.
    Liu, Yan
    Bunyatratchata, Apichaya
    Smilowitz, Jennifer T.
    Stahl, Bernd
    Barile, Daniela
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (26) : 6851 - 6859