Biological effects of combinations of structurally diverse human milk oligosaccharides

被引:1
|
作者
Wichmann, Anita [1 ]
机构
[1] DSM Firmenich, Global Regulatory Affairs HMOs Early Life & Med Nu, Horsholm, Denmark
来源
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词
human milk oligosaccharides; pediatric nutrition; gut microbiota; pathogen inhibition; cognitive development; SIALIC-ACID; ROTAVIRUS INFECTIVITY; NOROVIRUS INHIBITION; GUT; BINDING; SIALYLLACTOSE; CONSUMPTION; METABOLISM; GLYCANS; PIGLET;
D O I
10.3389/fped.2024.1439612
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Human milk oligosaccharides (HMOs) are a diverse group of structures and an abundant bioactive component of breastmilk that contribute to infant health and development. Preclinical studies indicate roles for HMOs in shaping the infant gut microbiota, inhibiting pathogens, modulating the immune system, and influencing cognitive development. In the past decade, several industrially produced HMOs have become available to fortify infant formula. Clinical intervention trials with manufactured HMOs have begun to corroborate some of the physiological effects reported in preclinical studies, especially modulation of the gut microbiota in the direction of breastfed infants. As more HMOs become commercially available and as HMOs have some shared mechanisms of action, there is a need to better understand the unique and differential effects of individual HMOs and the benefits of combining multiple HMOs. This review focuses on the differential effects of different HMO structural classes and individual structures and presents a scientific rationale for why combining multiple structurally diverse HMOs is expected to exert greater biological effects.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Recent Progress in Human Milk Oligosaccharides and Its Antiviral Efficacy
    Chen, Yihan
    Chen, Zhengxin
    Zhu, Yingying
    Wen, Yuxi
    Zhao, Chao
    Mu, Wanmeng
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (14) : 7607 - 7617
  • [22] Human Milk Oligosaccharides and Respiratory Syncytial Virus Infection in Infants
    Tonon, Karina M.
    Chutipongtanate, Somchai
    Morrow, Ardythe L.
    Newburg, David S.
    ADVANCES IN NUTRITION, 2024, 15 (06)
  • [23] Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner
    Pausan, Manuela-Raluca
    Kolovetsiou-Kreiner, Vassiliki
    Richter, Gesa Lucia
    Madl, Tobias
    Giselbrecht, Elisabeth
    Obermayer-Pietsch, Barbara
    Weiss, Eva-Christine
    Jantscher-Krenn, Evelyn
    Moissl-Eichinger, Christine
    MSYSTEMS, 2020, 5 (03)
  • [24] Gut microbiota: A key role for human milk oligosaccharides in regulating host health early in life
    Chen, Qingxue
    Ma, Xinming
    Guo, Zhengtao
    Zhang, Peng
    Li, Bailiang
    Wang, Zhongjiang
    COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 2024, 23 (05):
  • [25] Human Milk Oligosaccharides and Immune System Development
    Plaza-Diaz, Julio
    Fontana, Luis
    Gil, Angel
    NUTRIENTS, 2018, 10 (08):
  • [26] Human Milk Oligosaccharides: Defense Against Pathogens
    Townsend, Steven D.
    BREASTFEEDING MEDICINE, 2019, 14 : S5 - S6
  • [27] Immunomodulation by Human Milk Oligosaccharides: The Potential Role in Prevention of Allergic Diseases
    Zuurveld, Marit
    van Witzenburg, Nikita P.
    Garssen, Johan
    Folkerts, Gert
    Stahl, Bernd
    van't Land, Belinda
    Willemsen, Linette E. M.
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [28] Synthesis of asymmetrical multiantennary human milk oligosaccharides
    Prudden, Anthony R.
    Liu, Lin
    Capicciotti, Chantelle J.
    Wolfert, Margreet A.
    Wang, Shuo
    Gao, Zhongwei
    Meng, Lu
    Moremen, Kelley W.
    Boons, Geert-Jan
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (27) : 6954 - 6959
  • [29] Biology of human milk oligosaccharides: From basic science to clinical evidence
    Sprenger, Norbert
    Tytgat, Hanne L. P.
    Binia, Aristea
    Austin, Sean
    Singhal, Atul
    JOURNAL OF HUMAN NUTRITION AND DIETETICS, 2022, 35 (02) : 280 - 299
  • [30] Tailored Combinations of Human Milk Oligosaccharides Modulate the Immune Response in an In Vitro Model of Intestinal Inflammation
    Walsh, Clodagh
    Lane, Jonathan A.
    van Sinderen, Douwe
    Hickey, Rita M.
    BIOMOLECULES, 2024, 14 (12)