Selection signatures detection in Nelore, Gir, and Red Sindhi cattle breeds

被引：0

作者：

Genuino, Maria Victoria Henrique ^{[1
]}

Bessa, Ayrton Fernandes de Oliveira ^{[1
]}

da Silva, Roney Teixeira ^{[2
]}

Camara, Giovanna Maria dos Santos ^{[3
]}

Panetto, Joao Claudio do Carmo ^{[4
]}

Machado, Marco Antonio ^{[4
]}

Caetano, Sabrina Luzia ^{[2
]}

Ramos, Salvador Boccaletti ^{[2
]}

Munari, Danisio Prado ^{[2
]}

Sonstegard, Tad ^{[5
]}

da Silva, Marcos Vinicius Gualberto Barbosa ^{[4
]}

Buzanskas, Marcos Eli ^{[3
]}

机构：

[1] Univ Fed Paraiba UFPB, BR-58397000 Areia, PB, Brazil

[2] Sao Paulo State Univ UNESP, Sch Agr & Vet Sci FCAV, BR-14884900 Jaboticabal, SP, Brazil

[3] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci FMVZ, BR-18618681 Botucatu, SP, Brazil

[4] Embrapa Dairy Cattle, BR-36038330 Juiz De Fora, MG, Brazil

[5] Acceligen, 3388 Mike Collins Dr, Eagan, MN 55121 USA

来源：

MAMMALIAN GENOME | 2025年

关键词：

Adaptation genetics; Genetic selection; Haplotype analysis; Heat tolerance genes; Livestock genomics; Zebu cattle; POSITIVE SELECTION; FEED-EFFICIENCY; GENOME; HOLSTEIN; GENES; ASSOCIATION; TRAITS; SHEEP;

D O I：

10.1007/s00335-025-10125-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Technological advances in genomics and bioinformatics made it possible to study the genetic structure of breeds and understand genome changes caused by selection over generations. Our objective was to evaluate selection signatures (SS) in Nelore, Gir, and Red Sindhi cattle from Brazil and the Asian continent to identify divergent variants due to the history of formation and selection of populations, with a focus on the SS of animals from Brazil. Extended haplotype homozygosities between populations (XP-EHH), the ratio of site-specific extended haplotype homozygosity between populations (Rsb), and the allelic fixation index (Fst) were used to detect SS. Considering a window size of 50-kb, a non-sliding window approach was used to define SS regions. A total of 62, 57, and 72 genes were co-located within SS regions for Nelore, Gir, and Red Sindhi, respectively, and used to perform functional analyses per breed. Most genes were associated with productive and reproductive traits, while others were related to thermotolerance, the immune system, temperament, and coat color. The identified SS demonstrate how animal breeding programs shape the genetic makeup of these breeds to meet production system requirements, given that animals from Brazil and the Asian continent have undergone different selection processes. The identification of genes related to thermotolerance, temperament, and the immune system suggests specific alleles have enabled animals to adapt to environmental conditions and selection criteria in Brazil. Understanding SS can support breeding strategies for Nelore, Gir, and Red Sindhi cattle, contributing to enhanced resistance, adaptation, and productivity to meet food production demands.

引用

页码：557 / 572

页数：16